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新型止吐化合物多潘立酮(R 33182)的初步报告。一项试点研究。

Preliminary report of domperidone (R 33182), a new antiemetic compound. A pilot study.

作者信息

Helmers J H

出版信息

Acta Anaesthesiol Belg. 1977;28(4):245-50.

PMID:613705
Abstract

The effect of domperidone (R 33 812), a new antiemetic, was studied in 27 patients presenting with postoperative vomiting and staying for at least six hours in a recovery room. All patients received 4 mg domperidone intravenously because of the vomiting. Nineteen patients were fully protected during the subsequent 6 hours observation period, 8 patients required a second 4 mg-dose: only one of these 8 patients was not protected at all. No side-effects were observed.

摘要

对一种新型止吐药多潘立酮(R 33 812)的效果进行了研究,研究对象为27例术后呕吐且在恢复室停留至少6小时的患者。所有患者因呕吐均静脉注射了4毫克多潘立酮。在随后6小时的观察期内,19例患者得到了完全保护,8例患者需要再注射4毫克剂量:这8例患者中只有1例完全未得到保护。未观察到副作用。

相似文献

1
Preliminary report of domperidone (R 33182), a new antiemetic compound. A pilot study.新型止吐化合物多潘立酮(R 33182)的初步报告。一项试点研究。
Acta Anaesthesiol Belg. 1977;28(4):245-50.
2
Domperidone in the treatment of postoperative vomiting: a double-blind multicenter study.多潘立酮治疗术后呕吐:一项双盲多中心研究。
Anesth Analg. 1978 Nov-Dec;57(6):700-3.
3
The efficacy of Domperidone (R 33812) in the treatment of postoperative vomiting. A double-blind study with a placebo.多潘立酮(R 33812)治疗术后呕吐的疗效。一项与安慰剂对照的双盲研究。
Anaesthesist. 1980 Sep;29(9):490-3.
4
Domperidone (R 33 812) as an antiemetic in the treatment of postoperative vomiting. A double blind comparison between two different dosages (4 mg and 10 mg).多潘立酮(R 33 812)作为一种止吐药用于治疗术后呕吐。两种不同剂量(4毫克和10毫克)的双盲比较。
Acta Anaesthesiol Belg. 1979 Dec;30(4):265-72.
5
Comparison of domperidone, droperidol, and metoclopramide in the prevention and treatment of nausea and vomiting after balanced general anesthesia.多潘立酮、氟哌利多和甲氧氯普胺预防和治疗平衡全身麻醉后恶心呕吐的比较。
Anesth Analg. 1979 Sep-Oct;58(5):396-400. doi: 10.1213/00000539-197909000-00010.
6
Postoperative vomiting treated with domperidone. A double-blind comparison with metoclopramide and a placebo.多潘立酮治疗术后呕吐。与甲氧氯普胺和安慰剂的双盲对照研究。
Acta Anaesthesiol Belg. 1980;31(2):129-37.
7
Postoperative nausea and vomiting treated with domperidone (r 33812) an open and a double-blind study.
Anaesthesist. 1978 Nov;27(11):540-3.
8
Domperidone in the prevention of post-operative nausea and vomiting.
Postgrad Med J. 1979;55 Suppl 1:45-7.
9
A multicentre pilot study of parenteral and rectal administration of domperidone in the treatment of severe vomiting in children.多潘立酮经肠外和直肠给药治疗儿童严重呕吐的多中心试点研究。
Postgrad Med J. 1979;55 Suppl 1:43-4.
10
Cytostatic therapy-induced vomiting inhibited by domperidone. A double-blind cross-over study.
Biomedicine. 1978 Nov;29(7):242-4.

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Saudi J Gastroenterol. 2014 Sep-Oct;20(5):267-9. doi: 10.4103/1319-3767.141683.
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