Weihrauch T R, Förster C F, Krieglstein J
Postgrad Med J. 1979;55 Suppl 1:7-10.
Intraluminal manometry has been used in a series of five studies on healthy volunteers and patients, to examine the action of domperidone on lower oesophageal sphincter pressure (LOSP), on peristaltic contraction, amplitudes and on antral, pyloric and duodenal motility. Furthermore, the effect on gastric acid secretion, pH, secretory volume and serum gastrin levels was studied. It was found that domperidone increased LOSP significantly but was less effective in patients with symptomatic gastro-oesophageal reflux than in normal volunteers. The drug also increased the amplitude of oesophageal and duodenal peristalsis but had no effect on endogenous gastrin release or on gastric acid secretion. The results suggest that this drug may be useful in the treatment of gastro-oesophageal and gastroduodenal reflux. This potential benefit is enhanced by the absence of side effects even when given in high doses.
腔内测压法已用于对健康志愿者和患者的五项系列研究中，以研究多潘立酮对下食管括约肌压力（LOSP）、蠕动收缩、幅度以及胃窦、幽门和十二指肠动力的作用。此外，还研究了其对胃酸分泌、pH值、分泌量和血清胃泌素水平的影响。结果发现，多潘立酮能显著提高LOSP，但对有症状的胃食管反流患者的效果不如正常志愿者。该药物还增加了食管和十二指肠蠕动的幅度，但对内源性胃泌素释放或胃酸分泌没有影响。结果表明，这种药物可能对治疗胃食管反流和胃十二指肠反流有用。即使大剂量给药也没有副作用，这增强了这种潜在的益处。
