Bajaj Devansh, Akram Mohamad
Gastroenterology, Jagadguru Sri Shivarathreeshwara (JSS) Medical College, Mysore, IND.
Internal Medicine, Swami Rama Himalayan University, Dehradun, IND.
Cureus. 2023 Dec 21;15(12):e50927. doi: 10.7759/cureus.50927. eCollection 2023 Dec.
The commonest medications prescribed in functional dyspepsia are prokinetic agents, specifically domperidone. However, its administration at times elevates serum prolactin levels, which can lead to pathological hyperprolactinemia. The present study investigated the effect of 28 days of 30 mg domperidone therapy on prolactinemia in functional dyspepsia patients. We recruited 97 patients (60 men and 37 women, aged 18-80 years) who had functional dyspepsia diagnosed as per the Rome IV criteria. After taking a preliminary clinical history, we measured and compared serum prolactin levels at day 'zero' and day 'twenty-eight'. We found increased prolactin levels from day '0' to day '28' after treatment with domperidone in functional dyspepsia patients, specifically in male participants aged less than 40 years, who are married and belong to middle socioeconomic status. The most common functional dyspepsia symptom found was pain in the epigastric region. To conclude, our pragmatic domperidone-induced-hyperprolactinemia link warrants this side effect to be robustly taken into account while treating functional dyspepsia patients with domperidone.
功能性消化不良最常开具的药物是促动力剂，特别是多潘立酮。然而，其使用有时会升高血清催乳素水平，这可能导致病理性高催乳素血症。本研究调查了30毫克多潘立酮治疗28天对功能性消化不良患者催乳素血症的影响。我们招募了97名根据罗马IV标准诊断为功能性消化不良的患者（60名男性和37名女性，年龄在18 - 80岁之间）。在获取初步临床病史后，我们测量并比较了“零”天和“二十八”天的血清催乳素水平。我们发现，功能性消化不良患者在使用多潘立酮治疗后，从“0”天到“28”天催乳素水平升高，特别是年龄小于40岁、已婚且属于中等社会经济地位的男性参与者。最常见的功能性消化不良症状是上腹部疼痛。总之，我们基于实际情况发现的多潘立酮诱发高催乳素血症的关联表明，在用多潘立酮治疗功能性消化不良患者时，应充分考虑到这种副作用。
