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高伯兹定律是从复杂生物体各组成部分之间的相互依存关系中自然产生的。

The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms.

机构信息

Department of Applied Mathematics and Computer Science, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

出版信息

Sci Rep. 2024 Jan 12;14(1):1196. doi: 10.1038/s41598-024-51669-5.

Abstract

Understanding and facilitating healthy aging has become a major goal in medical research and it is becoming increasingly acknowledged that there is a need for understanding the aging phenotype as a whole rather than focusing on individual factors. Here, we provide a universal explanation for the emergence of Gompertzian mortality patterns using a systems approach to describe aging in complex organisms that consist of many inter-dependent subsystems. Our model relates to the Sufficient-Component Cause Model, widely used within the field of epidemiology, and we show that including inter-dependencies between subsystems and modeling the temporal evolution of subsystem failure results in Gompertizan mortality on the population level. Our model also provides temporal trajectories of mortality-risk for the individual. These results may give insight into understanding how biological age evolves stochastically within the individual, and how this in turn leads to a natural heterogeneity of biological age in a population.

摘要

理解和促进健康老龄化已成为医学研究的主要目标,人们越来越认识到,需要全面了解衰老表型,而不是专注于个别因素。在这里,我们使用系统方法为复杂生物体的衰老提供了一个普遍的解释,这些生物体由许多相互依赖的子系统组成。我们的模型与广泛应用于流行病学领域的充分组成因模型有关,我们表明,包括子系统之间的相互依赖关系,并对子系统故障的时间演变进行建模,会导致群体水平上出现戈梅茨死亡率。我们的模型还为个体的死亡率风险提供了时间轨迹。这些结果可能有助于理解个体内部的生物年龄如何随机进化,以及这反过来如何导致群体中生物年龄的自然异质性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4932/10786855/110744e614d5/41598_2024_51669_Fig1_HTML.jpg

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