Neurological Department of Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200333, China.
Neuroscience Research Center, Institute of Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710000, China.
Cell Commun Signal. 2024 Jan 12;22(1):34. doi: 10.1186/s12964-024-01483-3.
Synaptic transmission plays an important and time-sensitive role in the nervous system. Although the amplitude of neurotransmission is positively related to the intensity of external stimulus, whether stronger stimulus could trigger synaptic transmission faster remains unsolved. Our present work in the primary sensory system shows that besides the known effect of larger amplitude, stronger stimulus triggers the synaptic transmission faster, which is regulated by the earlier started action potential (AP), independent of the AP's amplitude. More importantly, this model is further extended from the sensory system to the hippocampus, implying broad applicability in the nervous system. Together, we found that stronger stimulus induces AP faster, which suggests to trigger the neurotransmission faster, implying that the occurrence time of neurotransmission, as well as the amplitude, plays an important role in the timely and effective response of nervous system.
突触传递在神经系统中起着重要且敏感的作用。尽管神经递质传递的幅度与外部刺激的强度呈正相关，但更强的刺激是否能更快地引发突触传递仍未得到解决。我们目前在初级感觉系统中的工作表明，除了已知的更大幅度的影响外，更强的刺激通过更早开始的动作电位（AP）更快地触发突触传递，而与 AP 的幅度无关。更重要的是，该模型从感觉系统进一步扩展到海马体，意味着在神经系统中有广泛的适用性。总的来说，我们发现更强的刺激会更快地引发 AP，这表明更快地触发神经递质传递，表明神经递质传递的发生时间和幅度在神经系统的及时有效反应中起着重要作用。
