中药及化合物治疗糖尿病肾病动物模型的肾脏保护作用：系统评价和荟萃分析方案。
Renal-protective effects of Chinese medicinal herbs and compounds for diabetic kidney disease in animal models: protocol for systematic review and meta-analysis.
机构信息
The China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
出版信息
Syst Rev. 2024 Jan 12;13(1):23. doi: 10.1186/s13643-023-02446-4.
BACKGROUND
Diabetic kidney disease (DKD) is a common and severe complication of diabetes that can lead to end-stage renal disease with no cure. The first-line drugs recommended by clinical guidelines fail to achieve satisfactory effects for people with DKD. A Chinese herbal medicine Tangshen Qushi Formula (TQF) shows preliminary efficacy and safety in preserving renal function for people with DKD, but the effects on comprehensive renal outcomes remain unclear. We will conduct a systematic review and meta-analysis to evaluate the effects of TQF herbs and their compounds identified from ultra-high performance liquid chromatography-MS/MS in diabetic animal models with renal outcomes.
METHODS
This protocol complies with the guideline Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. We will include studies investigating the effects of TQF herbs and compounds on diabetic rats or mice with renal outcomes. Six electronic databases will be searched from their inception to February 2023. Quality assessment will be conducted using SYRCLE's risk of bias tool. Standardized or weighted mean differences will be estimated for renal outcomes (creatinine, urea, proteinuria, histological changes, oxidative stress, inflammation, and kidney fibrosis). Data will be pooled using random-effects models. Heterogeneity across studies will be expressed as I. Sensitivity analyses will explore treatment effects in adjusted models and within subgroups. Funnel plots and Egger's test will be used to explore publication bias.
DISCUSSION
The results of this review will provide valuable insights into the potential effects of TQF in managing DKD. The limitation is that the included studies will be animal studies from specific databases, and the interpretation of the findings must be cautious.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42023432895. Registered on 19 July 2023 ( https://www.crd.york.ac.uk/PROSPERO/#recordDetails ).
背景
糖尿病肾病（DKD）是糖尿病的一种常见且严重的并发症，可导致终末期肾病，目前尚无治愈方法。临床指南推荐的一线药物对 DKD 患者的疗效并不理想。中药糖肾祛湿方（TQF）在保护 DKD 患者肾功能方面初步显示出疗效和安全性，但对综合肾脏结局的影响尚不清楚。我们将进行系统评价和荟萃分析，以评估 TQF 草药及其从超高效液相色谱-串联质谱法鉴定的化合物在具有肾脏结局的糖尿病动物模型中的作用。
方法
本方案符合系统评价和荟萃分析方案首选报告项目的指南。我们将纳入研究 TQF 草药及其化合物对具有肾脏结局的糖尿病大鼠或小鼠的影响的研究。将从创建到 2023 年 2 月检索 6 个电子数据库。使用 SYRCLE 的偏倚风险工具进行质量评估。将使用随机效应模型估计肾脏结局（肌酐、尿素、蛋白尿、组织学变化、氧化应激、炎症和肾脏纤维化）的标准化或加权均数差。将通过敏感性分析在调整模型和亚组内探索治疗效果。漏斗图和 Egger 检验将用于探索发表偏倚。
讨论
本综述的结果将为 TQF 管理 DKD 的潜在作用提供有价值的见解。局限性在于纳入的研究将是特定数据库中的动物研究，对研究结果的解释必须谨慎。
系统评价注册
PROSPERO CRD42023432895。于 2023 年 7 月 19 日注册（https://www.crd.york.ac.uk/PROSPERO/#recordDetails）。
Zotero 插件