Department of Otorhinolarynogology and head/neck surgery, Amsterdam University Medical Centres, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Otolaryngology, Head and Neck Surgery, Rhinology, A. Gemelli Universitary Hospital Foundation, IRCSS, Rome, Italy.
Rhinology. 2024 Jun 1;62(3):287-298. doi: 10.4193/Rhin23.415.
Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.
伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是一种弥漫性双侧疾病（通常为 2 型），是一种使人虚弱的疾病，对生活质量（QoL）有重大影响。随着新的知识和治疗方案的出现，人们越来越需要更新或修改关键定义，以促进处理 CRS 的不同专业之间的交流，并就 CRSwNP 的新治疗目标达成一致。欧洲过敏和气道疾病研究与教育论坛（EUFOREA）和 EPOS 专家成员讨论了如何衡量 CRSwNP 的治疗反应并设定新的治疗目标。本文就与 CRSwNP 相关的一系列定义达成了共识：控制、缓解、治愈、复发/加重、可治疗特征、重塑、进展和疾病修饰。通过提供这些定义，相关专家希望改善所有涉及 CRSwNP 治疗的利益相关者之间的沟通，以便在常规护理、基础和临床研究以及旨在协调和优化未来 CRSwNP 患者护理标准的国际指南中使用。
