Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang, China.
Second College of Clinical Medicine, Nanchang University, Nanchang, China.
Aging (Albany NY). 2024 Jan 11;16(1):714-745. doi: 10.18632/aging.205414.
Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies and its incidence and mortality continue apace. Lysosome-associated membrane protein 3 (LAMP3) is the third member of the LAMP family and its overexpression has been described to be involved in the progression of breast, ovarian and cervical cancers, but there has been an absence of research focusing on its role in UCEC.
WGCNA, TIMER, LinkedOmics, GSEA, Cytoscape, Kaplan-Meier plotter, GDC, GeneMANIA, cBioPortal, PDB, RNAinter, miRNet were applied in this research.
Our study uncovers that LAMP3 possesses higher expression levels in UCEC compared to normal tissues, and this differential expression profile is tightly aligned with clinical and pathological features, and patients demonstrating high LAMP3 expression tend to have a shorter survival expectancy. The high expression of LAMP3 is modulated by the designated ceRNA network. LAMP3 is engaged in UCEC progression by functioning in a variety of biological roles of relevance to immunity. Furthermore, we predicted several prospering drugs based on drug sensitivity. Finally, we also constructed possible docking patterns of LAMP3 with ABCA3, RAB9A, and SGTB.
LAMP3 is a formidable biomarker for UCEC and could be a prospective candidate for the diagnosis, treatment and prognostic assessment of UCEC.
子宫内膜癌（UCEC）是最常见的妇科恶性肿瘤之一，其发病率和死亡率持续上升。溶酶体相关膜蛋白 3（LAMP3）是 LAMP 家族的第三个成员，其过表达被描述为参与乳腺癌、卵巢癌和宫颈癌的进展，但尚未有研究关注其在 UCEC 中的作用。
本研究应用 WGCNA、TIMER、LinkedOmics、GSEA、Cytoscape、Kaplan-Meier plotter、GDC、GeneMANIA、cBioPortal、PDB、RNAinter、miRNet。
我们的研究表明，LAMP3 在 UCEC 中的表达水平高于正常组织，这种差异表达谱与临床和病理特征密切相关，表达水平高的患者的预期生存时间较短。LAMP3 的高表达受特定的 ceRNA 网络调节。LAMP3 通过在与免疫相关的多种生物学作用中发挥作用，参与 UCEC 的进展。此外，我们基于药物敏感性预测了几种有前途的药物。最后，我们还构建了 LAMP3 与 ABCA3、RAB9A 和 SGTB 可能的对接模式。
LAMP3 是 UCEC 的一种强大的生物标志物，可能是 UCEC 的诊断、治疗和预后评估的有前途的候选物。
