Zhang Shuyang, Han Xingyu
Medical College, China Three Gorges University, Yichang 443002, China.
J Oncol. 2022 Aug 29;2022:6458877. doi: 10.1155/2022/6458877. eCollection 2022.
Endometrial cancer is the 6th most common carcinoma as well as the 2nd most common malignancy worldwide in women. It is closely related to fat content, and dyslipidemia is among the most significant metabolic changes in this cancer. Therefore, further understanding of the regulation mechanism in lipid metabolism of endometrial cancer is conducive to the development of better therapeutic strategies and methods. Here, we systematically review the signaling pathways that regulate lipid metabolism in endometrial cancer and the research progress of drugs and targeted therapies that act on lipid metabolism by retrieving relevant articles. The underlying mechanism of occurrence and development of endometrial cancer is relatively clear and comprehensively reviewed here. But following more research studies will help to illuminate more specific regulatory roles of lipid metabolism in endometrial cancer and explore new possible mechanisms, prognostic and therapeutic targets, and subsequent drugs. Our review will provide a full view for the following investigation of lipid metabolism in endometrial cancer.
子宫内膜癌是全球女性中第六大常见癌症，也是第二大常见恶性肿瘤。它与脂肪含量密切相关，血脂异常是这种癌症中最显著的代谢变化之一。因此，进一步了解子宫内膜癌脂质代谢的调控机制有助于开发更好的治疗策略和方法。在此，我们通过检索相关文章，系统地综述了调节子宫内膜癌脂质代谢的信号通路以及作用于脂质代谢的药物和靶向治疗的研究进展。本文较为全面地综述了子宫内膜癌发生发展的潜在机制。但随着更多研究的开展，将有助于阐明脂质代谢在子宫内膜癌中更具体的调节作用，探索新的可能机制、预后和治疗靶点以及后续药物。我们的综述将为后续子宫内膜癌脂质代谢的研究提供全面的视角。
