Rössner P, Cerná M, Lepsi P, Pohlová H
Mutat Res. 1987 Mar;190(3):183-6. doi: 10.1016/0165-7992(87)90026-1.
The chromosome-breaking activity of four 1-(phenyl)-3,3-dimethyltriazenes was tested in vitro on human peripheral blood lymphocytes using S9 mix as a metabolic activation system. 1-(4-Nitrophenyl)-3,3-dimethyltriazene was the most active compound. The difference in the frequency of chromosomal aberrations in a test with and without metabolic activation was significant at the 1% level of significance. The lowest frequency of chromosomal aberrations was induced by 1-(4-methylphenyl)-3,3-dimethyltriazene which, under the conditions of this experiment, is the least stable and probably rapidly degraded to non-active compounds. The chromosomal aberrations were also induced by 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(4-bromophenyl)-3,3-dimethyltriazene, this activity was unrelated to metabolic activation.
使用S9混合物作为代谢活化系统，在体外对人外周血淋巴细胞测试了四种1 -（苯基）-3,3 -二甲基三氮烯的染色体断裂活性。1 -（4 -硝基苯基）-3,3 -二甲基三氮烯是活性最高的化合物。在有和没有代谢活化的测试中，染色体畸变频率的差异在1%的显著性水平上具有统计学意义。1 -（4 -甲基苯基）-3,3 -二甲基三氮烯诱导的染色体畸变频率最低，在本实验条件下，它最不稳定，可能会迅速降解为无活性的化合物。1 -（4 -氯苯基）-3,3 -二甲基三氮烯和1 -（4 -溴苯基）-3,3 -二甲基三氮烯也能诱导染色体畸变，这种活性与代谢活化无关。
