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用1-苯基-3,3-二甲基三氮烯和N-亚硝基吗啉对大鼠淋巴细胞进行体内处理后的染色体畸变。关于一种潜在致癌性筛查方法的进一步报告。

Chromosomal aberrations in rat lymphocytes treated in vivo with 1-phenyl-3, 3-dimethyltriazene and n-nitrosomorpholine. A further report on a possible method for carcinogenicity screening.

作者信息

Newton M F, Bahner B, Lilly L J

出版信息

Mutat Res. 1977 Sep;56(1):39-46. doi: 10.1016/0027-5107(77)90239-1.

Abstract

This paper reports the results of screening two carcinogens, N-nitrosomorpholine (NM) and 1-phenyl-3, 3-dimethyltriazene (PDT), for their ability to cause an increase in chromosomal aberrations in rat lymphocytes cultured in vitro after treatment in vivo. NM is a hepatocarcinogen and PDT induces tumours mainly of the central and peripheral nervous system. Both these chemicals gave only weakly positive results in certain other established short term screening tests for carcinogenicity, despite having been shown to cause a significant increase in the number of chromosomal aberrations after a single administration of doses of 250 mg/kg and above. These aberrations were mainly of the isolocus type as opposed to the chromatid type. Significant increases in the number of aberrations of both the isolocus and chromatid types were found after single applications of PDT of 35 and 50 mg/kg. The results obtained are compared with those of other workers using the same compounds in different test systems. Modifications of the system to increase its sensitivity are suggested.

摘要

本文报道了对两种致癌物N-亚硝基吗啉(NM)和1-苯基-3,3-二甲基三氮烯(PDT)进行筛选的结果,研究它们在体内处理后对体外培养的大鼠淋巴细胞染色体畸变率升高的影响。NM是一种肝癌致癌物,PDT主要诱发中枢和外周神经系统肿瘤。尽管已证明单次给予250mg/kg及以上剂量后,这两种化学物质会导致染色体畸变数量显著增加,但在其他某些既定的短期致癌性筛选试验中,它们仅给出弱阳性结果。这些畸变主要是等位点类型,而非染色单体类型。单次应用35mg/kg和50mg/kg的PDT后,发现等位点和染色单体类型的畸变数量均显著增加。将所得结果与其他研究人员在不同测试系统中使用相同化合物的结果进行了比较。建议对该系统进行改进以提高其灵敏度。

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