Department of Nephrology, The 2nd Xiangya Hospital, Central South University, Changsha, Hunan, China; Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Clin Chim Acta. 2024 Feb 1;554:117756. doi: 10.1016/j.cca.2023.117756. Epub 2024 Jan 12.
Irisin is a hormone that is produced mainly by skeletal muscles in response to exercise. It has been found to have a close correlation with obesity and diabetes mellitus for its energy expenditure and metabolic properties. Recent research has revealed that irisin also possesses anti-inflammatory, anti-oxidative and anti-apoptotic properties, which make it associated with major chronic diseases, such as chronic kidney disease (CKD), liver diseases, osteoporosis, atherosclerosis and Alzheimer s disease. The identification of irisin has not only opened up new possibilities for monitoring metabolic and non-metabolic diseases but also presents a promising therapeutic target due to its multiple biological functions. Studies have shown that circulating irisin levels are lower in CKD patients than in non-CKD patients and decrease with increasing CKD stage. Furthermore, irisin also plays a role in many CKD-related complications like protein energy wasting (PEW), cardiovascular disease (CVD) and chronic kidney disease-mineral and bone disorder (CKD-MBD). In this review, we present the current knowledge on the role of irisin in kidney diseases and their complications.
鸢尾素是一种激素，主要由骨骼肌在运动时产生。由于其能量消耗和代谢特性，它与肥胖症和糖尿病密切相关。最近的研究表明，鸢尾素还具有抗炎、抗氧化和抗凋亡特性，使其与慢性肾脏病 (CKD)、肝脏疾病、骨质疏松症、动脉粥样硬化和阿尔茨海默病等主要慢性疾病相关。鸢尾素的发现不仅为监测代谢和非代谢疾病开辟了新的可能性，而且由于其多种生物学功能，也为治疗提供了有前途的靶点。研究表明，CKD 患者的循环鸢尾素水平低于非 CKD 患者，并且随着 CKD 阶段的增加而降低。此外，鸢尾素在许多 CKD 相关并发症中也发挥作用，如蛋白能量消耗 (PEW)、心血管疾病 (CVD) 和慢性肾脏病-矿物质和骨异常 (CKD-MBD)。在这篇综述中，我们介绍了鸢尾素在肾脏疾病及其并发症中的作用的最新知识。
