转录起始前复合物与+1 核小体之间的相互作用。
Interplay between the transcription preinitiation complex and the +1 nucleosome.
机构信息
Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
出版信息
Trends Biochem Sci. 2024 Feb;49(2):145-155. doi: 10.1016/j.tibs.2023.12.001. Epub 2024 Jan 13.
Eukaryotic transcription starts with the assembly of a preinitiation complex (PIC) on core promoters. Flanking this region is the +1 nucleosome, the first nucleosome downstream of the core promoter. While this nucleosome is rich in epigenetic marks and plays a key role in transcription regulation, how the +1 nucleosome interacts with the transcription machinery has been a long-standing question. Here, we summarize recent structural and functional studies of the +1 nucleosome in complex with the PIC. We specifically focus on how differently organized promoter-nucleosome templates affect the assembly of the PIC and PIC-Mediator on chromatin and result in distinct transcription initiation.
真核生物转录起始于核心启动子上预起始复合物（PIC）的组装。在这个区域的侧翼是+1 核小体，即核心启动子下游的第一个核小体。虽然这个核小体富含表观遗传标记，在转录调控中起着关键作用，但+1 核小体与转录机制相互作用的方式一直是一个长期存在的问题。在这里，我们总结了最近关于与 PIC 复合物结合的+1 核小体的结构和功能研究。我们特别关注不同组织的启动子-核小体模板如何影响 PIC 和 PIC-Mediator 在染色质上的组装，并导致不同的转录起始。
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