Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Department of Radiology, City of Hope, Duarte, California.
J Vasc Interv Radiol. 2024 Jun;35(6):809-817.e1. doi: 10.1016/j.jvir.2024.01.005. Epub 2024 Jan 12.
Traditionally, rodent cancer models have driven preclinical oncology research. However, they do not fully recapitulate characteristics of human cancers, and their size poses challenges when evaluating tools in the interventional oncologists' armamentarium. Pig models, however, have been the gold standard for validating surgical procedures. Their size enables the study of image-guided interventions using human ultrasound (US), computed tomography (CT), and magnetic resonance (MR) imaging platforms. Furthermore, pigs have immunologic features that are similar to those of humans, which can potentially be leveraged for studying immunotherapy. Novel pig models of cancer are being developed, but additional research is required to better understand both the pig immune system and malignancy to enhance the potential for pig models in interventional oncology research. This review aims to address the main advantages and disadvantages of using a pig model for interventional oncology and outline the specific characteristics of pig models that make them more suitable for investigation of locoregional therapies.
传统上，啮齿动物癌症模型推动了临床前肿瘤学研究。然而，它们不能完全重现人类癌症的特征，而且当评估介入肿瘤学家武器库中的工具时，它们的体型带来了挑战。然而，猪模型一直是验证手术程序的金标准。它们的体型使人们能够使用人类超声（US）、计算机断层扫描（CT）和磁共振（MR）成像平台研究图像引导干预。此外，猪具有与人类相似的免疫特征，这可能被用于研究免疫疗法。目前正在开发新型猪癌症模型，但需要进一步的研究来更好地了解猪的免疫系统和恶性肿瘤，以提高猪模型在介入肿瘤学研究中的潜力。本综述旨在讨论使用猪模型进行介入肿瘤学的主要优缺点，并概述使猪模型更适合局部区域治疗研究的具体特征。
