Braga Ribanna Aparecida Marques, Bezerra Ilana Nogueira, Nogueira Maria Dinara de Araújo, Souza Amanda de Moura, Martins Géssica de Souza, Almondes Kaluce Gonçalves de Sousa, Moreno Luis Alberto, Maia Carla Soraya Costa
Postgraduate Program in Nutrition and Health, State University of Ceará, Fortaleza, Brazil.
Postgraduate Program in Nutrition and Health, State University of Ceará, Fortaleza, Brazil; Postgraduate Program in Collective Health, State University of Ceará, Fortaleza, Brazil.
Nutr Metab Cardiovasc Dis. 2024 Apr;34(4):1069-1079. doi: 10.1016/j.numecd.2023.12.016. Epub 2023 Dec 20.
Recently, new indices combining routine and low-cost anthropometric and biochemical measurements have emerged. Among them, the visceral adiposity index (VAI) and lipid accumulation product (LAP) are being investigated for the prediction of altered blood pressure (BP) and insulin resistance (IR). Therefore, this study aimed to evaluate whether visceral adiposity index (VAI) and height-corrected lipid accumulation product (HLAP) are predictors of cardiometabolic risk in Brazilian adolescents.
Data were obtained from the Cardiovascular Risk in Adolescents (ERICA) study, a cross-sectional, national, multicenter, school-based survey conducted between 2013 and 2014 in Brazil. The sample consisted of 37,815 adolescents aged 12-17 years of both genders attending the last 3 years of elementary or secondary school from public and private schools located in 273 municipalities with more than 100,000 inhabitants. A Poisson regression was performed to verify associations between VAI and HLAP indices and the presence of altered BP and IR according to sex. In addition, receiver operating characteristic curve (ROC) analysis was applied to compare the predictive ability and determine the cut-off points of the VAI and HLAP indices in identifying cardiometabolic risk obtained by altered BP and IR. The prevalences of altered BP and IR were 24.49 % (95 % confidence interval [CI]: 23.14-25.87) and 24.22 % (95 % CI: 22.70-25.80), respectively.
The VAI and HLAP indices are good predictors of cardiometabolic risk in Brazilian adolescents. HLAP showed better performance in identifying insulin resistance in males.
最近，出现了结合常规和低成本人体测量及生化测量的新指标。其中，内脏脂肪指数（VAI）和脂质蓄积产物（LAP）正在被研究用于预测血压（BP）变化和胰岛素抵抗（IR）。因此，本研究旨在评估内脏脂肪指数（VAI）和身高校正脂质蓄积产物（HLAP）是否为巴西青少年心血管代谢风险的预测指标。
数据来自青少年心血管风险（ERICA）研究，这是一项2013年至2014年在巴西开展的横断面、全国性、多中心、基于学校的调查。样本包括来自273个居民超过10万的城市中公立和私立学校的37815名12至17岁的青少年，他们均处于小学或初中最后三年。进行泊松回归以验证VAI和HLAP指数与根据性别划分的血压变化和IR存在之间的关联。此外，应用受试者工作特征曲线（ROC）分析来比较预测能力，并确定VAI和HLAP指数在识别由血压变化和IR得出的心血管代谢风险方面的切点。血压变化和IR的患病率分别为24.49%（95%置信区间[CI]：23.14 - 25.87）和24.22%（95%CI：22.70 - 25.80）。
VAI和HLAP指数是巴西青少年心血管代谢风险的良好预测指标。HLAP在识别男性胰岛素抵抗方面表现更佳。
