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miRNAs to the rescue: Reversing heart failure by targeting miR-29.

作者信息

Wang Xinghua, Anwar Iqra, Hodgkinson Conrad P

机构信息

Mandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Mol Ther Nucleic Acids. 2023 Dec 28;35(1):102105. doi: 10.1016/j.omtn.2023.102105. eCollection 2024 Mar 12.

DOI:10.1016/j.omtn.2023.102105
PMID:38222301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10787231/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c515/10787231/33e25aa01051/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c515/10787231/33e25aa01051/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c515/10787231/33e25aa01051/gr1.jpg

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1
miRNAs to the rescue: Reversing heart failure by targeting miR-29.微小RNA来拯救：通过靶向miR-29逆转心力衰竭
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2
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本文引用的文献

1
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix.miR-29的调节可能通过对钙处理和细胞外基质的协同调节来影响心肌顺应性。
Mol Ther Nucleic Acids. 2023 Nov 17;34:102081. doi: 10.1016/j.omtn.2023.102081. eCollection 2023 Dec 12.
2
Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity.成人心肌细胞和新生儿心肌细胞在心脏再生能力上存在固有差异。
J Biol Chem. 2023 May;299(5):104694. doi: 10.1016/j.jbc.2023.104694. Epub 2023 Apr 10.
3
RNA accessibility impacts potency of Tough Decoy microRNA inhibitors.
RNA 可及性影响 Tough Decoy 微 RNA 抑制剂的效力。
RNA Biol. 2018;15(11):1410-1419. doi: 10.1080/15476286.2018.1537746. Epub 2018 Nov 7.
4
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.心肌细胞 miR-29 通过激活 Wnt 信号促进心脏病理性重塑。
Nat Commun. 2017 Nov 20;8(1):1614. doi: 10.1038/s41467-017-01737-4.
5
Realizing the Full Potential of Precision Medicine in Health and Health Care.实现精准医学在健康与医疗保健中的全部潜力。
JAMA. 2016 Oct 25;316(16):1659-1660. doi: 10.1001/jama.2016.14117.
6
siRNA Versus miRNA as Therapeutics for Gene Silencing.作为基因沉默疗法的小干扰RNA与微小RNA
Mol Ther Nucleic Acids. 2015 Sep 15;4(9):e252. doi: 10.1038/mtna.2015.23.