Sato A, Sato Y, Shimamura K, Suzuki H
Neurosci Lett. 1986 Dec 23;72(3):309-14. doi: 10.1016/0304-3940(86)90532-x.
Sympathoadrenal medullary functions were investigated in stroke-prone spontaneously hypertensive rats (SHR-SP) and in control normotensive Wistar-Kyoto rats (WKY) under halothane-anesthetized and resting conditions. The mean frequency of the spontaneous efferent activity of a single adrenal sympathetic nerve fiber was 1.08 +/- 0.11 impulses/s in WKY and 2.82 +/- 0.24 imp/s in SHR-SP, indicating a much higher level in SHR-SP than in WKY. The secretion rates of both adrenaline and noradrenaline from the adrenal gland were higher in SHR-SP than in WKY. The secretion rates of adrenaline and noradrenaline in WKY were 16.8 +/- 3.0 and 1.70 +/- 0.09 ng/kg X min, respectively, while those in SHR-SP were 36.7 +/- 3.9 and 2.56 +/- 0.18 ng/kg X min, respectively.
在氟烷麻醉和静息条件下，对易中风自发性高血压大鼠（SHR-SP）和对照正常血压Wistar-Kyoto大鼠（WKY）的交感肾上腺髓质功能进行了研究。单根肾上腺交感神经纤维的自发传出活动平均频率在WKY中为1.08±0.11次冲动/秒，在SHR-SP中为2.82±0.24次冲动/秒，表明SHR-SP中的水平比WKY中的高得多。SHR-SP中肾上腺的肾上腺素和去甲肾上腺素分泌率均高于WKY。WKY中肾上腺素和去甲肾上腺素的分泌率分别为16.8±3.0和1.70±0.09纳克/千克·分钟，而SHR-SP中的分泌率分别为36.7±3.9和2.56±0.18纳克/千克·分钟。
