Mueller S M, Black W L
Stroke. 1985 Jan-Feb;16(1):73-5. doi: 10.1161/01.str.16.1.73.
Spontaneously hypertensive rats (SHR) have been shown to have an increased capacity for superior cervical sympathetic nerve activity which may protect against stroke (Mueller et al: Stroke 13: 115, 1982). Sympathetic nerve activity has never been examined in the stroke-prone substrain of SHR (SP). In this study we measured superior cervical sympathetic nerve activity during rest and during a maximal sympathetic response in SHR, SP, and their normotensive controls, Wistar-Kyoto (WKY). The resting superior cervical sympathetic nerve activity of SP was significantly less than SHR (p less than 0.02) but not different from WKY. During central ischemia, used to induce maximal sympathetic response, the increase in SP sympathetic nerve activity was significantly less than SHR (p less than 0.001) but was not different from WKY. This diminished capacity for elevated superior cervical sympathetic nerve activity in stroke-prone SHR may relate to their increased predisposition to stroke because sympathetic hyperactivity cannot protect cerebral vessels during acute hypertension.
自发性高血压大鼠（SHR）已被证明具有增强的颈上交感神经活动能力，这可能对预防中风有保护作用（Mueller等人：《中风》13：115，1982）。从未在易中风的SHR亚系（SP）中研究过交感神经活动。在本研究中，我们测量了SHR、SP及其正常血压对照Wistar-Kyoto（WKY）在静息状态和最大交感反应期间的颈上交感神经活动。SP的静息颈上交感神经活动明显低于SHR（p<0.02），但与WKY无差异。在用于诱导最大交感反应的中枢缺血期间，SP交感神经活动的增加明显低于SHR（p<0.001），但与WKY无差异。易中风的SHR中颈上交感神经活动升高的能力减弱，可能与其中风易感性增加有关，因为在急性高血压期间交感神经过度活跃无法保护脑血管。
