Arvidson B
Neurotoxicology. 1986 Fall;7(3):89-96.
Adult rats were injected intravenously with 109CdCl2 and the distribution of the isotope within the brain and neighboring nervous structures was subsequently studied by autoradiography. Cadmium accumulated in regions outside the blood-brain barrier such as the choroid plexus, pineal gland and area postrema, but did not appear in the brain parenchyma. Uptake of cadmium was observed in the trigeminal ganglia close to the nerve cells and in the olfactory bulbs. In addition, cadmium accumulated in the iris, ciliary body and choroid of the eye, but not in the optic nerves. The deposition of cadmium in the olfactory bulbs may be related to the anosmia reported in workers exposed to this metal. The possible harmful effects of accumulation of cadmium in restricted regions of the brain and adjacent nervous structures are discussed.
给成年大鼠静脉注射109氯化镉，随后通过放射自显影术研究该同位素在脑及邻近神经结构中的分布。镉积聚在血脑屏障之外的区域，如脉络丛、松果体和最后区，但未出现在脑实质中。在靠近神经细胞的三叉神经节和嗅球中观察到镉的摄取。此外，镉积聚在眼的虹膜、睫状体和脉络膜中，但未积聚在视神经中。镉在嗅球中的沉积可能与接触这种金属的工人所报告的嗅觉丧失有关。文中讨论了镉在脑的特定区域和邻近神经结构中积聚可能产生的有害影响。
