关于孟加拉国乙肝病毒基因型特定模式的叙述性综述：管理的临床意义
A Narrative Review on the Specific Pattern of HBV Genotype in Bangladesh: Clinical Implications for Management.
作者信息
Raihan Ruksana, Akbar Sheikh Mohammad Fazle
机构信息
Department of Microbiology, US Bangla Medical College and Hospital, University of Malaya, Dhaka, Bangladesh.
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine; Research Center for Global and Local Infectious Diseases, Faculty of Medicine, Oita University, Oita; Miyakawa Memorial Research Foundation, Tokyo, Japan.
出版信息
Euroasian J Hepatogastroenterol. 2023 Jul-Dec;13(2):152-158. doi: 10.5005/jp-journals-10018-1412.
BACKGROUND AND AIMS
Bangladesh's unique epidemiological landscape presents an intriguing puzzle. This South Asian nation, with its complex sociodemographic and environmental factors, is home to a diverse array of hepatitis-B virus (HBV) genotypes, identified as Genotype C, with Genotypes D and A also making a significant contribution to the viral landscape. Reviewing such insights is necessary not only to underscore the country's regional diversity in HBV strains but also to bring into focus the clinical implications these genetic variations may have on disease progression and management.
METHODS
A thorough database search covered various sources using relevant keywords like "Hepatitis B virus genotypes", "HBV genotypes in Bangladesh", and "HBV clinical implications". The review synthesized findings and analyzed HBV genotype prevalence and clinical implications in Bangladesh.
RESULTS
Genotypes C and D collectively represent 82% of chronic hepatitis-B infection (CHB) cases in Bangladesh, underscoring their regional prevalence. The geographic context is pivotal in understanding HBV infection dynamics and disease progression in this area. Notably, genotype C and the presence of A1762T/G1764A mutations appear to have a distinct impact on disease development, potentially affecting the immune response in CHB patients. This highlights the need for tailored management approaches in this specific region. Further research is vital to confirm and elaborate on these findings, particularly in relation to how these mutations influence the host's immune response.
CONCLUSION AND CLINICAL SIGNIFICANCE
In summary, studies on HBV genotypes in Bangladesh stress the need for genotype-specific clinical considerations and more research to improve diagnostics and therapies.
HOW TO CITE THIS ARTICLE
Raihan R, Akbar SMF. A Narrative Review on the Specific Pattern of HBV Genotype in Bangladesh: Clinical Implications for Management. Euroasian J Hepato-Gastroenterol 2023;13(2):152-158.
背景与目的
孟加拉国独特的流行病学格局呈现出一个有趣的谜题。这个南亚国家，因其复杂的社会人口和环境因素，是多种乙肝病毒（HBV）基因型的家园，其中C基因型最为常见，D和A基因型在病毒格局中也占据显著比例。回顾这些见解不仅有助于凸显该国HBV毒株的区域多样性，还能聚焦这些基因变异可能对疾病进展和管理产生的临床影响。
方法
通过使用“乙肝病毒基因型”、“孟加拉国的HBV基因型”和“HBV临床意义”等相关关键词，对各种来源进行全面的数据库搜索。本综述综合了研究结果，并分析了孟加拉国HBV基因型的流行情况及其临床意义。
结果
C和D基因型共同占孟加拉国慢性乙肝感染（CHB）病例的82%，凸显了它们在该地区的流行程度。地理背景对于理解该地区HBV感染动态和疾病进展至关重要。值得注意的是，C基因型以及A1762T/G1764A突变的存在似乎对疾病发展有独特影响，可能影响CHB患者的免疫反应。这凸显了在这个特定地区采取针对性管理方法的必要性。进一步的研究对于证实和详细阐述这些发现至关重要，特别是关于这些突变如何影响宿主免疫反应。
结论与临床意义
总之，关于孟加拉国HBV基因型的研究强调了针对基因型进行临床考量的必要性，以及开展更多研究以改善诊断和治疗的重要性。
如何引用本文
Raihan R, Akbar SMF. A Narrative Review on the Specific Pattern of HBV Genotype in Bangladesh: Clinical Implications for Management. Euroasian J Hepato-Gastroenterol 2023;13(2):152-158.
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