白细胞介素-12 +1188A/C 多态性与结核病风险的关联：荟萃分析。
Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis.
机构信息
Department of Tuberculosis,Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Cardiology, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Afr Health Sci. 2023 Jun;23(2):133-138. doi: 10.4314/ahs.v23i2.15.
BACKGROUND
The role of gene +1188A/C polymorphism has been indicated in the progression of tuberculosis (TB). Nevertheless, the outcomes remain controversial.
OBJECTIVES
This meta-analysis focused on examining the association between +1188A/C polymorphism and TB.
METHODS
EMBASE and PubMed databases were searched to identify relevant studies for retrospective analysis. Then, a random- or fixed-effects model was utilized to calculate the combined odds ratios (ORs) as well as corresponding 95% confidence intervals (CIs).
RESULTS
A total of 9 related articles were discovered. The result of meta-analysis showed that +1188A/C polymorphism did not show significant correlation with TB risk among the total population (C vs A: OR =0.66, 95% CI=0.41-1.05; AC vs AA: OR = 1.28, 95% CI =0.90-1.82; CC vs AA: OR =0.95, 95% CI=0.80-1.14; recessive model: OR =1.00, 95% CI = 0.75-1.34; dominant model: OR =1.07, 95% CI =0.94-1.21). As discovered from subgroup analyses based on race and HWE, this polymorphism did not show relationship with TB risk.
CONCLUSION
The present findings indicated that +1188A/C polymorphism was not related to the risk of TB.
背景
基因+1188A/C 多态性在结核病（TB）的进展中起作用。然而，结果仍存在争议。
目的
本荟萃分析重点研究+1188A/C 多态性与 TB 之间的关联。
方法
检索 EMBASE 和 PubMed 数据库以进行回顾性分析。然后，使用随机或固定效应模型计算合并的优势比（OR）和相应的 95％置信区间（CI）。
结果
共发现 9 篇相关文章。荟萃分析的结果表明，+1188A/C 多态性与总体人群的 TB 风险之间没有显著相关性（C 与 A：OR=0.66，95％CI=0.41-1.05；AC 与 AA：OR=1.28，95％CI=0.90-1.82；CC 与 AA：OR=0.95，95％CI=0.80-1.14；隐性模型：OR=1.00，95％CI=0.75-1.34；显性模型：OR=1.07，95％CI=0.94-1.21）。基于种族和 HWE 的亚组分析发现，这种多态性与 TB 风险无关。
结论
目前的研究结果表明，+1188A/C 多态性与 TB 风险无关。
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