Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
Parkinson's Disease Unit, University Hospital of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
J Neural Transm (Vienna). 2024 Mar;131(3):239-244. doi: 10.1007/s00702-024-02739-5. Epub 2024 Jan 16.
REM sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD), and the timing of its presentation might have a role in the underlying neurodegenerative process. Here, we aimed to define the potential impact of probable RBD (pRBD) on PD motor progression.We conducted a longitudinal retrospective study on 66 PD patients followed up at the University Hospital of Rome Tor Vergata. Patients were divided into three groups: with post-motor pRBD (pRBD, n = 25), without pRBD (pRBD, n = 20), and with pre-motor pRBD (pRBD, n = 21). Hoehn and Yahr (H&Y) scores, Unified PD Rating Scale (UPDRS) motor scores, and levodopa equivalent daily dose were collected at two follow-up visits conducted in a 5-year interval (T0 and T1). pRBD patients had a greater rate of motor progression in terms of the H&Y scale compared to pRBD and pRBD patients, without the influence of anti-parkinsonian treatment.These preliminary findings suggest that the post-motor occurrence of pRBD can be associated with an acceleration in PD motor progression.
快速眼动睡眠行为障碍（RBD）是帕金森病（PD）的常见非运动症状，其出现的时间可能与潜在的神经退行性过程有关。在这里，我们旨在确定可能的 RBD（pRBD）对 PD 运动进展的潜在影响。我们对在罗马 Tor Vergata 大学医院接受随访的 66 名 PD 患者进行了一项纵向回顾性研究。患者分为三组：有运动后 pRBD（pRBD，n=25）、无 pRBD（pRBD，n=20）和有运动前 pRBD（pRBD，n=21）。在 5 年的随访间隔内（T0 和 T1）采集 Hoehn 和 Yahr（H&Y）评分、统一帕金森病评定量表（UPDRS）运动评分和左旋多巴等效日剂量。与 pRBD 和 pRBD 患者相比，pRBD 患者的 H&Y 量表显示出更大的运动进展速度，而不受抗帕金森病治疗的影响。这些初步发现表明，pRBD 的运动后发生可能与 PD 运动进展的加速有关。
