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Does MgSO4 protect the preterm brain? Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy.

作者信息

Galinsky Robert, Bennet Laura, Gunn Alistair J

机构信息

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.

Department of Obstetrics and Gynaecology, Monash University, Melbourne, VIC, Australia.

出版信息

Neural Regen Res. 2024 Sep 1;19(9):1861-1862. doi: 10.4103/1673-5374.390977. Epub 2023 Dec 15.

DOI:10.4103/1673-5374.390977
PMID:38227499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11040324/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969c/11040324/a709042ba697/NRR-19-1861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969c/11040324/a709042ba697/NRR-19-1861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/969c/11040324/a709042ba697/NRR-19-1861-g001.jpg

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Does MgSO4 protect the preterm brain? Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy.硫酸镁能保护早产儿大脑吗？剖析其在缺氧缺血性脑病病理生理学中的作用。
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2
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本文引用的文献

1
Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep.硫酸镁可减少三级神经胶质增生，但不能改善窒息后早产胎儿羊的脑电图恢复或白质和灰质细胞存活。
J Physiol. 2023 May;601(10):1999-2016. doi: 10.1113/JP284381. Epub 2023 Apr 13.
2
A Systematic Review of Magnesium Sulfate for Perinatal Neuroprotection: What Have We Learnt From the Past Decade?硫酸镁用于围产期神经保护的系统评价：过去十年我们学到了什么？
Front Neurol. 2020 May 27;11:449. doi: 10.3389/fneur.2020.00449. eCollection 2020.
3
Motor learning promotes remyelination via new and surviving oligodendrocytes.
运动学习通过新的和存活的少突胶质细胞促进髓鞘再生。
Nat Neurosci. 2020 Jul;23(7):819-831. doi: 10.1038/s41593-020-0637-3. Epub 2020 May 18.
4
Short-term effects of early initiation of magnesium infusion combined with cooling after hypoxia-ischemia in term piglets.足月仔猪缺氧缺血后早期给予镁输注联合冷却的短期影响。
Pediatr Res. 2019 Dec;86(6):699-708. doi: 10.1038/s41390-019-0511-8. Epub 2019 Jul 29.
5
Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy.硫酸镁预防脑瘫小鼠行为障碍和脑损伤的时间和性别依赖性疗效。
Neurobiol Dis. 2018 Dec;120:151-164. doi: 10.1016/j.nbd.2018.08.020. Epub 2018 Sep 7.
6
Time and sex dependent effects of magnesium sulphate on post-asphyxial seizures in preterm fetal sheep.硫酸镁对早产胎儿羊窒息后发作的时间和性别依赖性影响。
J Physiol. 2018 Dec;596(23):6079-6092. doi: 10.1113/JP275627. Epub 2018 Apr 16.
7
Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis.评估产前硫酸镁对婴儿的神经保护作用：一项个体参与者数据荟萃分析。
PLoS Med. 2017 Oct 4;14(10):e1002398. doi: 10.1371/journal.pmed.1002398. eCollection 2017 Oct.
8
Magnesium sulfate reduces EEG activity but is not neuroprotective after asphyxia in preterm fetal sheep.硫酸镁可降低早产胎羊窒息后的脑电图活动，但并无神经保护作用。
J Cereb Blood Flow Metab. 2017 Apr;37(4):1362-1373. doi: 10.1177/0271678X16655548. Epub 2016 Jan 1.
9
Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep.硫酸镁与早产胎羊对窒息的心血管和脑血管适应性
J Physiol. 2016 Mar 1;594(5):1281-93. doi: 10.1113/JP270614. Epub 2015 Jul 8.
10
School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo.产前用硫酸镁治疗与安慰剂治疗对极早产儿学龄期结局的影响。
JAMA. 2014 Sep 17;312(11):1105-13. doi: 10.1001/jama.2014.11189.