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在一名患有酒精使用障碍、焦虑和创伤的患者中,连接神经科学和临床评估。

Bridging Neuroscience and Clinical Assessment in a Patient with Alcohol Use Disorder, Anxiety, and Trauma.

出版信息

J Psychiatr Pract. 2024 Jan 1;30(1):62-67. doi: 10.1097/PRA.0000000000000763.

DOI:10.1097/PRA.0000000000000763
PMID:38227730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10795724/
Abstract

This article presents a unique framework that combines insights from neuroscience with clinical assessment to evaluate individuals who have co-occurring alcohol use disorder, anxiety, and trauma. Through the use of a case study, the authors demonstrate the practical application of this framework and contextualize the relevant neurocircuitry associated with alcohol withdrawal, maladaptive fear and anxiety, and chronic stress. By integrating these perspectives, they provide a comprehensive approach for assessing and treating patients with complex psychiatric histories, particularly those presenting with anxiety symptoms, offering valuable insights for practitioners.

摘要

本文提出了一个独特的框架,结合了神经科学和临床评估的见解,用于评估同时患有酒精使用障碍、焦虑和创伤的个体。通过使用案例研究,作者展示了该框架的实际应用,并将与酒精戒断、适应不良的恐惧和焦虑以及慢性应激相关的相关神经回路置于上下文中。通过整合这些观点,他们为评估和治疗具有复杂精神病史的患者提供了一种综合方法,特别是那些表现出焦虑症状的患者,为从业者提供了有价值的见解。

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本文引用的文献

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The Overlapping Neurobiology of Induced and Pathological Anxiety: A Meta-Analysis of Functional Neural Activation.诱导性焦虑和病理性焦虑的神经生物学重叠:功能神经激活的荟萃分析。
Am J Psychiatry. 2021 Feb 1;178(2):156-164. doi: 10.1176/appi.ajp.2020.19111153. Epub 2020 Oct 15.
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Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial.加巴喷丁治疗伴有酒精戒断症状的酒精使用障碍患者的疗效:一项随机临床试验。
JAMA Intern Med. 2020 May 1;180(5):728-736. doi: 10.1001/jamainternmed.2020.0249.
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Resting-state causal connectivity of the bed nucleus of the stria terminalis in panic disorder.
惊恐障碍患者终纹床核的静息状态因果连通性。
Brain Imaging Behav. 2021 Feb;15(1):25-35. doi: 10.1007/s11682-019-00229-x.
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Prefrontal Cortical and Limbic Circuit Alterations in Psychopathology.精神病理学中的前额叶皮质和边缘系统回路改变
Am J Psychiatry. 2019 Dec 1;176(12):971-973. doi: 10.1176/appi.ajp.2019.19101036.
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Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder.神经功能域源自酒精使用障碍的深度行为表型。
Am J Psychiatry. 2019 Sep 1;176(9):744-753. doi: 10.1176/appi.ajp.2018.18030357. Epub 2019 Jan 4.
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Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan.童年不良经历及其对一生的神经生物学、心理社会和躯体状况的影响。
Front Psychiatry. 2018 Sep 4;9:420. doi: 10.3389/fpsyt.2018.00420. eCollection 2018.
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Novel Algorithms for the Prophylaxis and Management of Alcohol Withdrawal Syndromes-Beyond Benzodiazepines.酒精戒断综合征预防与管理的新算法——超越苯二氮䓬类药物
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Distinct phasic and sustained brain responses and connectivity of amygdala and bed nucleus of the stria terminalis during threat anticipation in panic disorder.惊恐障碍患者在预期威胁时杏仁核和终纹床核的不同时相和持续的大脑反应和连接。
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Integrating a Neuroscience Perspective Into Clinical Psychiatry Today.将神经科学视角融入当代临床精神病学。
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