Olufosoye Oludamilola, Soler Roxana, Babagbemi Kemi
Central Michigan University, College of Medicine, Mount Pleasant, MI 48858, United States of America.
Nova Southeastern University, College of Allopathic Medicine, Ft Lauderdale, FL 33328, United States of America.
Clin Imaging. 2024 Mar;107:110066. doi: 10.1016/j.clinimag.2023.110066. Epub 2023 Dec 14.
Women from racial and ethnic minorities are at a higher risk for developing breast cancer. Despite significant advancements in breast cancer screening, treatment, and overall survival rates, disparities persist among Black and Hispanic women. These disparities manifest as breast cancer at an earlier age with worse prognosis, lower rates of genetic screening, higher rates of advanced-stage diagnosis, and higher rates of breast cancer mortality compared to Caucasian women. The underutilization of available resources, such as genetic testing, counseling, and risk assessment tools, by Black and Hispanic women is one of many reasons contributing to these disparities. This review aims to explore the racial disparities that exist in genetic testing among Black and Hispanic women. Barriers that contribute to racial disparities include limited access to resources, insufficient knowledge and awareness, inconsistent care management, and slow progression of incorporation of genetic data and information from women of racial/ethnic minorities into risk assessment models and genetic databases. These barriers continue to impede rates of genetic testing and counseling among Black and Hispanic mothers. Consequently, it is imperative to address these barriers to promote early risk assessment, genetic testing and counseling, early detection rates, and ultimately, lower mortality rates among women belonging to racial and ethnic minorities.
来自少数种族和族裔的女性患乳腺癌的风险更高。尽管在乳腺癌筛查、治疗和总体生存率方面取得了重大进展,但黑人和西班牙裔女性之间的差距仍然存在。这些差距表现为乳腺癌发病年龄更早、预后更差、基因筛查率更低、晚期诊断率更高,以及与白人女性相比乳腺癌死亡率更高。黑人和西班牙裔女性对可用资源(如基因检测、咨询和风险评估工具)利用不足是导致这些差距的众多原因之一。本综述旨在探讨黑人和西班牙裔女性在基因检测方面存在的种族差异。导致种族差异的障碍包括资源获取有限、知识和意识不足、护理管理不一致,以及将种族/族裔少数群体女性的基因数据和信息纳入风险评估模型和基因数据库的进展缓慢。这些障碍继续阻碍黑人和西班牙裔母亲进行基因检测和咨询的比例。因此,必须消除这些障碍,以促进早期风险评估、基因检测和咨询、提高早期检测率,并最终降低少数种族和族裔女性的死亡率。