Department of Sciences, Ophthalmology Clinic, National Center of High Technology in Ophthalmology, Gabriele D'Annunzio University, Via dei Vestini, 66100, Chieti, Italy.
Department of Medical Oral Science and Biotechnology, G. d'Annunzio University of Chieti-Pescara Chieti, Via dei Vestini 31, Chieti, Italy.
Sci Rep. 2024 Jan 16;14(1):1370. doi: 10.1038/s41598-024-51183-8.
Animal models have demonstrated that structural changes affect the macula during peripheral rhegmatogenous retinal detachment. This study aimed to assess photoreceptors, retinal and choriocapillaris perfusion in non-macula involving rhegmatogenous retinal detachment by analyzing en-face images from structural OCTA segmented at the ellipsoid zone (EZ) level, calculating (1) "normalized" reflectivity as a surrogate biomarker of photoreceptor damage (2) perfusion density (PD), vessel length density (VLD) and vessel diameter index (VDI) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) (3) perfusion density of choriocapillaris (PDCC). Twenty-one eyes affected by macula-on rhegmatogenous retinal detachment (RRD) were enrolled at the University "G. d'Annunzio", Chieti-Pescara. The fellow unaffected eye was used as control. The mean age at the onset of RRD was 60.09 ± 10.22 (range 34-83). Compared with fellow eyes, we found lower EZ "normalized" reflectivity in macula-on (0.42 ± 0.15 in fellow eyes and 0.31 ± 0.09 in macula on p = 0.004). The affected eye was also characterized by impaired perfusion in SCP (17.26 ± 3.34% in macula on and 20.56 ± 3.62% in the fellow eye p = 0.004) and CC (50.21 ± 6.20% in macula on the eye and 57.43 ± 6.20% in the fellow eye p = 0.004). Macula-on rhegmatogenous retinal detachment has subclinical changes in photoreceptors, SCP, and CC. Future longitudinal studies should evaluate if early changes could impact post-operative macular function.
动物模型已经表明，在周边孔源性视网膜脱离期间，结构变化会影响黄斑。本研究旨在通过分析在椭圆体带（EZ）水平分割的结构 OCTA 的 en-face 图像，评估非黄斑区孔源性视网膜脱离的光感受器、视网膜和脉络膜毛细血管灌注，计算（1）作为光感受器损伤替代生物标志物的“归一化”反射率，（2）浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的灌注密度（PD）、血管长度密度（VLD）和血管直径指数（VDI），（3）脉络膜毛细血管（PDCC）的灌注密度。在基耶蒂-佩斯卡拉的“G. d'Annunzio”大学，纳入了 21 只患有黄斑区孔源性视网膜脱离（RRD）的患眼。对侧未受影响的眼睛作为对照。RRD 发病时的平均年龄为 60.09±10.22 岁（范围 34-83 岁）。与对侧眼相比，我们发现黄斑区受累的 EZ“归一化”反射率较低（对侧眼为 0.42±0.15，黄斑区受累眼为 0.31±0.09，p=0.004）。受影响的眼睛还表现出 SCP 灌注受损（黄斑区受累眼为 17.26±3.34%，对侧眼为 20.56±3.62%，p=0.004）和 CC（黄斑区受累眼为 50.21±6.20%，对侧眼为 57.43±6.20%，p=0.004）。黄斑区受累的孔源性视网膜脱离在光感受器、SCP 和 CC 中存在亚临床变化。未来的纵向研究应评估早期变化是否会影响术后黄斑功能。
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