School of Pharmacy/School of Modem Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People's Republic of China.
Department of Biology, New York University, New York, NY, USA.
Vet Res Commun. 2024 Apr;48(2):649-663. doi: 10.1007/s11259-024-10294-3. Epub 2024 Jan 16.
It is widely acknowledged that we are currently facing a critical tipping point with regards to global extinction, with human activities driving us perilously close to the brink of a devastating sixth mass extinction. As a promising option for safeguarding endangered species, induced pluripotent stem cells (iPSCs) hold great potential to aid in the preservation of threatened animal populations. For endangered species, such as the northern white rhinoceros (Ceratotherium simum cottoni), supply of embryos is often limited. After the death of the last male in 2019, only two females remained in the world. IPSC technology offers novel approaches and techniques for obtaining pluripotent stem cells (PSCs) from rare and endangered animal species. Successful generation of iPSCs circumvents several bottlenecks that impede the development of PSCs, including the challenges associated with establishing embryonic stem cells, limited embryo sources and immune rejection following embryo transfer. To provide more opportunities and room for growth in our work on animal welfare, in this paper we will focus on the progress made with iPSC lines derived from endangered and extinct species, exploring their potential applications and limitations in animal welfare research.
人们普遍认识到，我们目前正处于全球灭绝的关键时刻，人类活动使我们危险地接近毁灭性的第六次大灭绝的边缘。诱导多能干细胞（iPSC）作为保护濒危物种的一种有前途的选择，具有很大的潜力来帮助保护受到威胁的动物种群。对于濒危物种，如北方白犀牛（Ceratotherium simum cottoni），胚胎的供应通常是有限的。2019 年最后一只雄性犀牛死亡后，世界上只剩下两只雌性犀牛。iPSC 技术为从稀有和濒危动物物种中获得多能干细胞（PSCs）提供了新的方法和技术。成功生成 iPSC 可以绕过阻碍 PSCs 发展的几个瓶颈，包括建立胚胎干细胞、胚胎来源有限以及胚胎移植后免疫排斥等相关挑战。为了在动物福利方面的工作提供更多的机会和发展空间，本文将重点介绍从濒危和灭绝物种中获得的 iPSC 系的进展，探索它们在动物福利研究中的潜在应用和局限性。
