Huffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Paratus Sciences, 430 East 29th Street, Suite 600, New York, NY 10016, USA.
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell. 2023 Mar 2;186(5):957-974.e28. doi: 10.1016/j.cell.2023.01.011. Epub 2023 Feb 21.
Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However, there are currently no reliable cellular models for studying bat biology or their response to viral infections. Here, we created induced pluripotent stem cells (iPSCs) from two species of bats: the wild greater horseshoe bat (Rhinolophus ferrumequinum) and the greater mouse-eared bat (Myotis myotis). The iPSCs from both bat species showed similar characteristics and had a gene expression profile resembling that of cells attacked by viruses. They also had a high number of endogenous viral sequences, particularly retroviruses. These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences and may have a more intertwined relationship with viruses than previously thought. Further study of bat iPSCs and their differentiated progeny will provide insights into bat biology, virus host relationships, and the molecular basis of bats' special traits.
蝙蝠因其能够飞行、使用喉返声定位和耐受病毒而在哺乳动物中独具特色。然而，目前还没有可靠的细胞模型可用于研究蝙蝠生物学或它们对病毒感染的反应。在这里，我们从两种蝙蝠物种（中华菊头蝠和大耳菊头蝠）中创建了诱导多能干细胞（iPSC）。这两种蝙蝠的 iPSC 表现出相似的特征，其基因表达谱类似于受到病毒攻击的细胞。它们还具有大量的内源性病毒序列，特别是逆转录病毒。这些结果表明，蝙蝠已经进化出了耐受大量病毒序列的机制，它们与病毒的关系可能比之前认为的更为密切。进一步研究蝙蝠 iPSC 及其分化后代将为蝙蝠生物学、病毒宿主关系以及蝙蝠特殊特征的分子基础提供新的认识。
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