Soejima K, Landing B H
Pediatr Pathol. 1986;6(2-3):289-99. doi: 10.3109/15513818609037719.
Ribs and vertebrae of 8 children and young adults aged from 17 months to 24 years with juvenile-onset diabetes mellitus, 4 with diabetes secondary to cystic fibrosis and 2 with diabetes secondary to thalassemia major, were analyzed for osteoporosis by a point-count morphometric method. The mean ratio of bone spicule to marrow space in cancellous bone of ribs of patients with juvenile-onset diabetes mellitus or with diabetes mellitus secondary to cystic fibrosis or thalassemia was 55% that of 10 control patients. The lengths of the zones of proliferating and mature cartilage cells in costal epiphyses of patients with juvenile-onset diabetes mellitus were also below normal. The ratio of bone spicule to marrow space of vertebrae of the diabetic patients was not significantly different from control values. The data confirm clinical reports that osteoporosis is a regular feature of juvenile-onset diabetes mellitus and suggest that the degree of bone matrix and mineral deficiency in such patients is greater than is usually considered.
采用点计数形态计量法，对8名年龄在17个月至24岁之间患有青少年型糖尿病的儿童和年轻人、4名继发于囊性纤维化的糖尿病患者以及2名继发于重型地中海贫血的糖尿病患者的肋骨和椎骨进行骨质疏松分析。青少年型糖尿病患者、继发于囊性纤维化或地中海贫血的糖尿病患者肋骨松质骨中骨小梁与骨髓腔的平均比例为10名对照患者的55%。青少年型糖尿病患者肋骨骺中增殖软骨细胞和成熟软骨细胞区域的长度也低于正常水平。糖尿病患者椎骨的骨小梁与骨髓腔比例与对照值无显著差异。这些数据证实了临床报告，即骨质疏松是青少年型糖尿病的常见特征，并表明此类患者的骨基质和矿物质缺乏程度比通常认为的要严重。
