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青少年糖尿病中的骨质减少

Osteopenia in juvenile diabetes.

作者信息

Shore R M, Chesney R W, Mazess R B, Rose P G, Bargman G J

出版信息

Calcif Tissue Int. 1981;33(5):455-7. doi: 10.1007/BF02409473.

DOI:10.1007/BF02409473
PMID:6797697
Abstract

The bone mineral status of fifty-one children with diabetes mellitus was studied by single photon absorptiometry. The mean bone mineral content was 13% below values predicted by age, sex, height, and weight. Those children whose diabetes was one year or less in duration were as osteopenic as those whose diabetes was of longer duration. The demineralized children received a higher daily insulin dose than others. No association was noted between the degree of skeletal demineralization and sex, statural growth, renal function, and serum calcium and phosphorus. No significant changes in bone mineral content were noted longitudinally.

摘要

采用单光子吸收法对51例糖尿病患儿的骨矿物质状况进行了研究。平均骨矿物质含量比根据年龄、性别、身高和体重预测的值低13%。糖尿病病程在1年或1年以下的患儿与病程较长的患儿一样存在骨质减少。骨质脱矿的患儿每日胰岛素剂量高于其他患儿。未发现骨骼脱矿程度与性别、身高增长、肾功能以及血清钙和磷之间存在关联。纵向观察未发现骨矿物质含量有显著变化。

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2
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Increased levels of Dickkopf-1 are indicative of Wnt/β-catenin downregulation and lower osteoblast signaling in children and adolescents with type 1 diabetes mellitus, contributing to lower bone mineral density.Dickkopf-1 水平升高表明 Wnt/β-连环蛋白下调和 1 型糖尿病患儿和青少年成骨细胞信号转导降低,导致骨密度降低。
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A new perspective on mechanisms governing skeletal complications in type 1 diabetes.1型糖尿病骨骼并发症发病机制的新视角
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Effect of targeted delivery of bone morphogenetic protein-2 on bone formation in type 1 diabetes.

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Diminution of bone mass in childhood diabetes.儿童糖尿病患者的骨质减少
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Osteopenia in insulin treated diabetes mellitus. Its relation to age at onset, sex and duration of disease.胰岛素治疗的糖尿病中的骨质减少。其与发病年龄、性别及病程的关系。
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Bone mineral status measured by direct photon absorptiometry in childhood renal disease.采用直接光子吸收法测定儿童肾脏疾病中的骨矿物质状况。
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Bone mineral loss in insulin-treated diabetes mellitus: studies on pathogenesis.
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Experimental diabetes reduces circulating 1,25-dihydroxyvitamin D in the rat.实验性糖尿病会降低大鼠体内循环的1,25-二羟维生素D水平。
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