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载药共晶介孔硅纳米粒子：药物释放的制备、表征和机制研究综述。

Drug-Coformer Loaded-Mesoporous Silica Nanoparticles: A Review of the Preparation, Characterization, and Mechanism of Drug Release.

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java 45363, Indonesia.

Pharmaceutical Technology and Drug Delivery, Department of Pharmacy, Universitas Sebelas Maret, Surakarta, Central Java, 57126, Indonesia.

出版信息

Int J Nanomedicine. 2024 Jan 12;19:281-305. doi: 10.2147/IJN.S449159. eCollection 2024.

DOI:10.2147/IJN.S449159
PMID:38229702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10790662/
Abstract

Drug-coformer systems, such as coamorphous and cocrystal, are gaining recognition as highly effective strategies for enhancing the stability, solubility, and dissolution of drugs. These systems depend on the interactions between drug and coformer to prevent the conversion of amorphous drugs into the crystalline form and improve the solubility. Furthermore, mesoporous silica (MPS) is also a promising carrier commonly used for stabilization, leading to solubility improvement of poorly water-soluble drugs. The surface interaction of drug-MPS and the nanoconfinement effect prevent amorphous drugs from crystallizing. A novel method has been developed recently, which entails the loading of drug-coformer into MPS to improve the solubility, dissolution, and physical stability of the amorphous drug. This method uses the synergistic effects of drug-coformer interactions and the nanoconfinement effect within MPS. Several studies have reported successful incorporation of drug-coformer into MPS, indicating the potential for significant improvement in dissolution characteristics and physical stability of the drug. Therefore, this study aimed to discuss the preparation and characterization of drug-coformer within MPS, particularly the interaction in the nanoconfinement, as well as the impact on drug release and physical stability.

摘要

药物共晶体系，如共无定形物和共晶体，作为提高药物稳定性、溶解度和溶解速率的有效策略得到了广泛的认可。这些体系依赖于药物与共晶形成物之间的相互作用，以防止无定形药物转化为晶体形式，并提高溶解度。此外，介孔硅（MPS）也是一种常用的稳定化载体，可提高难溶性药物的溶解度。药物-MPS 的表面相互作用和纳米限域效应可防止无定形药物结晶。最近开发了一种新方法，即将药物共晶负载到 MPS 中，以提高无定形药物的溶解度、溶解速率和物理稳定性。该方法利用药物共晶相互作用和 MPS 内纳米限域效应的协同作用。已有多项研究报道成功地将药物共晶负载到 MPS 中，表明该方法有可能显著改善药物的溶解特性和物理稳定性。因此，本研究旨在讨论药物共晶在 MPS 中的制备和表征，特别是纳米限域内的相互作用，以及对药物释放和物理稳定性的影响。

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