Aulifa Diah Lia, Amarilis Bunga, Ichsani Luthfia Nur, Maharani Devita Salsa, Shabrina Ayunda Myela, Hanifah Hanifah, Wulandari Rizky Prasiska, Rusdin Agus, Subra Laila, Budiman Arif
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Bandung 45363, Indonesia.
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Bandung 45363, Indonesia.
Pharmaceuticals (Basel). 2024 Dec 13;17(12):1684. doi: 10.3390/ph17121684.
Medicinal plants are increasingly being explored due to their possible pharmacological properties and minimal adverse effects. However, low bioavailability and stability often limit efficacy, necessitating high oral doses to achieve therapeutic levels in the bloodstream. Mesoporous silica nanoparticles (MSNs) offer a potential solution to these limitations. Due to their large surface area, substantial pore volume, and ability to precisely control pore size. MSNs are also capable of efficiently incorporating a wide range of therapeutic substances, including herbal plant extracts, leading to potential use for drug containment and delivery systems. Therefore, this review aimed to discuss and summarize the successful developments of herbal plant extracts loaded into MSN, focusing on preparation, characterization, and the impact on efficacy. Data were collected from publications on Scopus, PubMed, and Google Scholar databases using the precise keywords "mesoporous silica nanoparticle" and "herbal extract". The results showed that improved phytoconstituent bioavailability, modified release profiles, increased stability, reduced dose and toxicity are the primary benefits of this method. This review offers insights on the significance of integrating MSNs into therapeutic formulations to improve pharmacological characteristics and effectiveness of medicinal plant extracts. Future prospects show favorable potential for therapeutic applications using MSNs combined with herbal medicines for clinical therapy.
药用植物因其潜在的药理特性和最小的副作用而越来越受到关注。然而，低生物利用度和稳定性常常限制其疗效，因此需要高口服剂量才能在血液中达到治疗水平。介孔二氧化硅纳米颗粒（MSNs）为这些限制提供了一个潜在的解决方案。由于其大的表面积、大量的孔体积以及精确控制孔径的能力，MSNs还能够有效地包载多种治疗物质，包括草药提取物，从而有可能用于药物包封和递送系统。因此，本综述旨在讨论和总结载入MSN的草药提取物的成功进展，重点关注其制备、表征以及对疗效的影响。使用精确关键词“介孔二氧化硅纳米颗粒”和“草药提取物”从Scopus、PubMed和谷歌学术数据库的出版物中收集数据。结果表明，改善植物成分的生物利用度、改变释放曲线、提高稳定性、降低剂量和毒性是该方法的主要优点。本综述提供了关于将MSNs整合到治疗制剂中以改善药用植物提取物的药理特性和有效性的重要性的见解。未来前景显示，使用MSNs与草药联合用于临床治疗具有良好的治疗应用潜力。
