Plummer Patrick D, Yglesias Benjamin, Giuseppucci Pablo
Department of Surgery, Trumbull Regional Medical Center, Warren, USA.
Cureus. 2023 Dec 17;15(12):e50674. doi: 10.7759/cureus.50674. eCollection 2023 Dec.
Medullary carcinoma (MC) is a rare subtype of colorectal cancer, which presents with poorly differentiated histology and is often confused with conventional adenocarcinoma of the colon. While this form of colorectal cancer is rare, it often does not meet the high-risk criteria to qualify for adjuvant chemotherapy even with a favorable prognosis. Diagnosis of MC is a proven difficulty because of the lack of immunohistochemical stains on pathology seen in adenocarcinoma of the colon. Unlike adenocarcinoma of the colon, distant metastasis is rare. Patients diagnosed with MC have one- and two-year survival rates of 93% and 74%, respectively. The patient was a 75-year-old female diagnosed with MC of the sigmoid colon and a large uterine fibroid. In this case report, we discuss the high-risk indications of colorectal cancer and the recommended treatment of patients with stage II MC of the colon.
髓样癌（MC）是结直肠癌的一种罕见亚型，其组织学分化差，常与结肠传统腺癌相混淆。虽然这种结直肠癌形式罕见，但即使预后良好，它通常也不符合辅助化疗的高危标准。由于结肠腺癌病理检查缺乏免疫组化染色，MC的诊断确实存在困难。与结肠腺癌不同，远处转移罕见。诊断为MC的患者1年和2年生存率分别为93%和74%。该患者为一名75岁女性，诊断为乙状结肠MC和巨大子宫肌瘤。在本病例报告中，我们讨论了结直肠癌的高危指征以及结肠II期MC患者的推荐治疗方法。
