结肠髓样癌：一项组织病理学挑战。
Medullary Carcinoma of the Colon: A Histopathologic Challenge.
作者信息
Fatima Zainab, Sharma Purva, Youssef Bahaaeldin, Krishnan Koyamangalath
机构信息
Internal Medicine, East Tennessee State University, Johnson City, USA.
Medical Oncology, East Tennessee State University, Johnson City, USA.
出版信息
Cureus. 2021 Jun 22;13(6):e15831. doi: 10.7759/cureus.15831. eCollection 2021 Jun.
Abstract
Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge.
摘要
结肠髓样癌（MC）是一种罕见且独特的结直肠癌组织学亚型。它通常与错配修复蛋白缺陷相关，并且与林奇综合征密切相关。由于其在病理检查中没有结直肠腺癌常见的免疫组化染色表现，因此诊断具有挑战性。在此，我们讨论一例有趣的结肠髓样癌病例，该病例在初诊时已发生转移，构成了诊断难题。
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