Destro Francesco, Hur Inyoung, Wang Vivian, Abdi Mesfin, Feng Xin, Wood Erin, Coleman Simon, Firth Paul, Barton Alastair, Barolo Massimiliano, Nagy Zoltan K
CAPE-Lab - Computer-Aided Process Engineering Laboratory, Department of Industrial Engineering, University of Padova, 35131 Padova PD, Italy.
Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47906, USA.
Chem Eng Sci. 2021;244. doi: 10.1016/j.ces.2021.116803. Epub 2021 Nov 23.
This paper introduces a comprehensive mathematical model of a novel integrated filter-dryer carousel system, designed for continuously filtering, washing and drying a slurry stream into a crystals cake. The digital twin includes models for dead-end filtration, cake washing and convective cake drying, based on dynamic multi-component mass, energy and momentum balances. For set of feed conditions and control inputs, the model allows tracking the solvents and impurities content in the cake (critical quality attributes, CQAs) throughout the whole process. The model parameters were identified for the isolation of paracetamol from a multi-component slurry, containing a non-volatile impurity. The calibrated model was used for identifying the probabilistic design space and maximum throughput for the process, expressing the combinations of the carousel feed conditions and control inputs for which the probability of meeting the target CQAs is acceptable.
本文介绍了一种新型集成过滤-干燥转盘系统的综合数学模型，该系统旨在将料浆流连续过滤、洗涤并干燥成晶体饼。数字孪生模型包括基于动态多组分质量、能量和动量平衡的死端过滤、滤饼洗涤和对流滤饼干燥模型。对于一组进料条件和控制输入，该模型能够在整个过程中跟踪滤饼中的溶剂和杂质含量（关键质量属性，CQAs）。针对从含有非挥发性杂质的多组分料浆中分离扑热息痛的过程确定了模型参数。校准后的模型用于确定该过程的概率设计空间和最大产量，即表示转盘进料条件和控制输入的组合，在这些组合下满足目标CQAs的概率是可接受的。
