encodes protein Cep152, which associates with centrosome function. The lack of Cep152 can cause centrosome duplication to fail. mutates, causing several diseases such as Seckel syndrome-5 and primary microencephaly-9.  In this study, we reported a patient diagnosed with epilepsy in Tianjin Children's Hospital. We performed clinical examination and laboratory test, and whole-exome sequencing was performed for the proband's and his parents' peripheral blood. The suspected compound-heterozygous variant in the gene was verified by Sanger sequencing and quantitative real-time polymerase chain reaction technology.  We discovered three variants-two of them from and one from . The result showed the variants in only. The patient presented with seizures frequently. Sanger sequencing showed two novel variants in are in exon26 (NM_014985.3 c.3968C > A p.Ser1323*) and in exon16 (NM_014985.3 c.2034_2036del p.Tyr678*).  We reported a novel compound-heterozygous variant in the gene in this study. Most of the phenotypes are Seckel syndrome and primary microencephaly, and the novel variant may cause an atypical phenotype that is epilepsy.