Dobbelstein H, Pielsticker K, Schreiber M A, Schubert G, Thoenes G H
Res Exp Med (Berl). 1979 May 30;175(2):169-80. doi: 10.1007/BF01851824.
The combined effect of Vitamin B6 free diet and 4-Desoxipyridoxin (a potent Vitamin B6-Antagonist) on the rejection reaction of inbred rats after renal transplantation was investigated. More than 90% of the control animals without Vitamin B6-deficiency died between 7 and 13 days with uremia due to an acute transplant rejection, where as the Vitamin deficient and successfully transplanted animals (n=38) showed a significantly prolonged survival time. In 17/38 rats survival was longer than 35 days. Vitamin B6-deficiency, induced by Desoxipyridoxin and Vitamin B6-deficient diet offers the possibility of an effective and reversible immunosuppression in renal transplantation.
研究了无维生素B6饮食和4-脱氧吡哆醇（一种有效的维生素B6拮抗剂）对近交系大鼠肾移植后排斥反应的联合作用。超过90%没有维生素B6缺乏的对照动物在7至13天内死于急性移植排斥导致的尿毒症，而缺乏维生素且移植成功的动物（n = 38）存活时间显著延长。在38只大鼠中有17只存活时间超过35天。由脱氧吡哆醇和缺乏维生素B6的饮食诱导的维生素B6缺乏为肾移植中有效且可逆的免疫抑制提供了可能性。
