Dobbelstein H, Baumgärtner R, Schubert G, Thoenes G
Res Exp Med (Berl). 1977 Jan 28;169(3):189-202. doi: 10.1007/BF01852058.
The influence of a Vitamin B6 free diet and the effect of Desoxipyridoxin (a potent Vitamin B6 Antagonist) on the immunesystem of mice was investigated in several experimental setups. Rejection times of skintransplants from inbred strains (129 J) on C57bl/6J mice served as a model for immunosuppression. Rejection times under alimentary Vitamin B6 deficiency did not exceed those under hypocaloric nutrition associated with comparable weight loss. Immunosuppression with the Vitamin B6 antagonist Desoxipyridoxin was much more pronounced. The effect was related to the duration of treatment. Desoxipyridoxin offers the possibility of effective immunsuppression, which is readily reversible.
在多个实验设置中，研究了无维生素B6饮食以及去氧吡哆醇（一种有效的维生素B6拮抗剂）对小鼠免疫系统的影响。将近交系（129 J）的皮肤移植到C57bl/6J小鼠身上的排斥时间用作免疫抑制的模型。在饮食性维生素B6缺乏情况下的排斥时间未超过与体重减轻相当的低热量营养情况下的排斥时间。用维生素B6拮抗剂去氧吡哆醇进行的免疫抑制更为明显。该效应与治疗持续时间有关。去氧吡哆醇提供了有效免疫抑制的可能性，且这种抑制很容易逆转。
