Germann G K, Eriksson E, Russell R C, Mody N
Plast Reconstr Surg. 1987 Mar;79(3):375-80. doi: 10.1097/00006534-198703000-00010.
Twelve pig buttock island flaps (10 X 10 cm) were studied for 6 hours after arteriovenous flow reversal at the level of the pedicle. Follow-up was 48 hours. Blood pressure, Po2, pH, and lactate were measured in flap arteries and veins. Oxygen consumption was calculated. Data indicated true flow reversal. Blood pressure and Po2 in flap veins increased to systemic arterial levels. Outflow was provided by the arterial system, demonstrating venous pressure and Po2 values. Lactate increased significantly (1.8 +/- 0.5 to 4.0 +/- 2.3 mmol/liter), while pH dropped from 7.43 +/- 0.03 to 7.11 +/- 0.02. Oxygen consumption remained below baseline. In four flaps thrombosis occurred within 6 hours; no flap survived 48 hours. The results of this study do not encourage clinical application of the concept of flow reversal.
对12个猪臀部岛状皮瓣（10×10厘米）在蒂部进行动静脉血流逆转后研究6小时。随访48小时。测量皮瓣动脉和静脉中的血压、氧分压、pH值和乳酸水平。计算氧耗量。数据表明存在真正的血流逆转。皮瓣静脉中的血压和氧分压升高至体循环动脉水平。由动脉系统提供流出道，显示出静脉压和氧分压值。乳酸显著增加（从1.8±0.5毫摩尔/升增至4.0±2.3毫摩尔/升），而pH值从7.43±0.03降至7.11±0.02。氧耗量仍低于基线水平。在4个皮瓣中，6小时内发生血栓形成；没有皮瓣存活至48小时。本研究结果不支持血流逆转概念的临床应用。
