Mackinnon S E, Hudson A R, Bain J R, Falk R E, Hunter D A
Plast Reconstr Surg. 1987 Mar;79(3):436-46.
Regeneration across the nerve allograft in the immunosuppressed host was assessed using electrical and histologic parameters. The Lewis rat (RTIl) served as the recipient animal, and ACI rats (RTIa) provided the donor nerve allografts. Hydrocortisone and azathioprine were used in various dose schedules as the immunosuppressive agents. Animals were immunosuppressed for either 30 or 100 days. Histologic and electrophysiologic measurements of nerve regeneration were assessed at 30, 100, and 180 days. The degree of nerve regeneration was similar in all experimental groups. Short-term, low-dose immunosuppression was as successful as longer-term, higher-dose immunosuppression therapy. The degree of nerve regeneration in all experimental groups was significantly better than that in the fresh, untreated nerve allograft control group (Lewis/ACI) but was not as good as that seen in the autograft control group (Lewis/Lewis).
利用电学和组织学参数评估了免疫抑制宿主中神经同种异体移植物的再生情况。刘易斯大鼠（RTIl）作为受体动物，ACI大鼠（RTIa）提供供体神经同种异体移植物。氢化可的松和硫唑嘌呤以不同剂量方案用作免疫抑制剂。动物接受30天或100天的免疫抑制。在第30、100和180天评估神经再生的组织学和电生理学测量结果。所有实验组的神经再生程度相似。短期、低剂量免疫抑制与长期、高剂量免疫抑制治疗同样成功。所有实验组的神经再生程度明显优于新鲜、未处理的神经同种异体移植对照组（刘易斯/ACI），但不如自体移植对照组（刘易斯/刘易斯）。
