Mackinnon S E, Hudson A R, Falk R E, Hunter D A
Ann Plast Surg. 1985 Apr;14(4):334-9. doi: 10.1097/00000637-198504000-00006.
The nerve allograft response in a rat model is presented. The Lewis rat (RTI1) served as the recipient animal while Fischer rats (RTI1) and ACI rats (RTIa) provided the donor nerve allografts. A Lewis/Lewis autograft group was used as the control group. Histological and electrophysiological measurements of nerve regeneration were assessed at five months. While good regeneration was noted in the autograft and matched allograft groups, regeneration across the unmatched allograft was poor. The degree of nerve regeneration (as measured with histological and electrophysiological values) correlated well with previous immunological studies and would support the use of this model for future investigation of the nerve allograft response in the rat.
本文介绍了大鼠模型中的神经同种异体移植反应。以Lewis大鼠（RTI1）作为受体动物，而Fischer大鼠（RTI1）和ACI大鼠（RTIa）提供供体神经同种异体移植物。将Lewis/Lewis自体移植组用作对照组。在五个月时评估神经再生的组织学和电生理学指标。虽然自体移植组和匹配的同种异体移植组显示出良好的再生，但不匹配的同种异体移植的再生情况较差。神经再生程度（通过组织学和电生理学指标衡量）与先前的免疫学研究结果高度相关，这将支持该模型用于未来大鼠神经同种异体移植反应的研究。
