Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Sci Total Environ. 2024 Mar 10;915:170113. doi: 10.1016/j.scitotenv.2024.170113. Epub 2024 Jan 15.
Pesticides are chemical substances of natural or synthetic origin that are used to eradicate pests and insects. These are indispensable in the agricultural processes for better crop production. Pesticide use aims to promote crop yield and protect the crops from diseases and damage. Pesticides must be handled carefully and disposed of appropriately because they are dangerous to people and other species by default. Environmental pollution occurs when pesticide contamination spreads away from the intended plants. Older pesticides such as lindane and dichlorodiphenyltrichloroethane (DDT) may remain in water and soil for a longer time. These accumulate in various parts of the food chain and cause damage to the ecosystem. Biological techniques in the management of pest control such as importation, augmentation, and conservation, and the accompanying procedures are more efficient, less expensive, and ecologically sound than other ways. This review mainly focuses on the consequences on the targeted and non-targeted organisms including the health and well-being of humans by the use of pesticides and their toxicity. The side effects that occur when a pesticide's LD exceeds the accepted limit through oral or skin penetration due to their binding to various receptors such as estrogen receptors, GABA, EGFR, and others. These pesticide classes include carbamates, pyrethroids, organochlorides, organophosphorus, and others. The current study seeks to highlight the urgent requirement for a novel agricultural concept that includes a major reduction in the use of chemical pesticides.
农药是天然或合成的化学物质,用于消灭害虫和昆虫。在农业生产中,这些物质对于提高作物产量是必不可少的。使用农药的目的是促进作物产量,并保护作物免受疾病和损害。由于农药对人类和其他物种默认是危险的,因此必须小心处理和妥善处置。当农药污染从预期的植物传播开来时,就会发生环境污染。较旧的农药,如林丹和滴滴涕(DDT),可能会在水中和土壤中停留更长时间。这些农药会在食物链的各个部分积累,并对生态系统造成损害。与其他方法相比,害虫管理中的生物技术,如引入、增加和保护,以及伴随的程序更有效、更经济实惠且对生态友好。本综述主要关注使用农药及其毒性对目标和非目标生物(包括人类的健康和福祉)造成的影响。当由于与各种受体(如雌激素受体、GABA、EGFR 等)结合,农药的 LD 超过可接受的限制(通过口服或皮肤渗透)时,会发生副作用。这些农药类别包括氨基甲酸酯类、拟除虫菊酯类、有机氯类、有机磷类等。本研究旨在强调迫切需要一种新的农业概念,包括大幅减少化学农药的使用。