沙特人群中[具体基因名称]和[具体基因名称]基因的遗传多态性与吸烟易感性
Genetic Polymorphisms of and Genes and Smoking Susceptibility in the Saudi Population.
作者信息
Al-Zahrani Maryam Hassan, Almutairi Nawal Marzoog
机构信息
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
出版信息
J Pharm Bioallied Sci. 2023 Oct-Dec;15(4):180-189. doi: 10.4103/jpbs.jpbs_365_23. Epub 2023 Dec 11.
BACKGROUND/OBJECTIVE/METHODS: Glutathione-S-transferase Mu1 () and glutathione peroxidase 1 () are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking. This study explored the correlation between and levels between a group of smokers with the and genes in the Saudi population and a control group and investigated the genetic risk factors in the group of smokers.
RESULTS
The control and smokers' group ( = 50; aged 22.3 ± 3.1 years; BMI 24.6 ± 5.9 kg/m) were genotyped using quantitative polymerase chain reaction (qPCR). In comparison with the control group, the smokers' group displayed a different genotype disruption of and . Carriers of the homozygous (TT) genotype of had more than a twofold (OR = 2.71, 95% CI = 0.10-70.79, = 1.000) smoking risk than the carriers of the heterozygous (CT) genotype. Those with the gene showed no risk in the control and smokers' groups. Smokers with the TT/GG combination (homozygous for and normal for ) were identified as high risk (OR = 2.58, 95% CI = 0.096-69.341).
CONCLUSION
The main outcomes showed no significant association between genetic polymorphism of the and genes and cigarette smoking in the Saudi Arabian population. However, the results showed a slight decrease in the number of and gene modifications among smokers.
背景/目的/方法：谷胱甘肽 - S - 转移酶Mu1（）和谷胱甘肽过氧化物酶1（）是已知的抗氧化酶，有助于保护细胞免受吸烟引起的氧化损伤。本研究探讨了沙特人群中一组携带和基因的吸烟者与对照组之间和水平的相关性，并调查了吸烟者组中的遗传风险因素。
结果
使用定量聚合酶链反应（qPCR）对对照组和吸烟者组（= 50；年龄22.3±3.1岁；BMI 24.6±5.9 kg/m）进行基因分型。与对照组相比，吸烟者组显示出和的不同基因型破坏。基因纯合（TT）基因型的携带者比杂合（CT）基因型的携带者有超过两倍（OR = 2.71，95% CI = 0.10 - 70.79，= 1.000）的吸烟风险。携带基因的人在对照组和吸烟者组中均未显示出风险。携带TT/GG组合（基因纯合且正常）的吸烟者被确定为高风险（OR = 2.58，95% CI = 0.096 - 69.341）。
结论
主要结果表明，沙特阿拉伯人群中和基因的遗传多态性与吸烟之间无显著关联。然而，结果显示吸烟者中和基因修饰的数量略有减少。
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