Hosaka Masaki, Nagasawa Shota, Iwabuchi Yoshiharu
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan.
Org Lett. 2024 Jan 26;26(3):658-663. doi: 10.1021/acs.orglett.3c04019. Epub 2024 Jan 18.
A catalytic method for the C-H alkylation of cubanes is described. Some hydrogen atom transfer catalysts enable the direct abstraction of a hydrogen atom from the C-H bond of cubanes, followed by conjugate addition of the generated cubyl radicals to electron-deficient alkenes. Synthetic applications of the functionalization method developed are also described.
描述了一种用于立方烷C-H烷基化的催化方法。一些氢原子转移催化剂能够直接从立方烷的C-H键中提取氢原子，随后生成的立方基自由基与缺电子烯烃发生共轭加成。还描述了所开发的官能团化方法的合成应用。
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