Hamilton R D, Winning A J, Guz A
Respir Physiol. 1987 Feb;67(2):159-70. doi: 10.1016/0034-5687(87)90038-7.
To determine whether local anesthetic aerosol could selectively block a reflex thought to originate from the alveoli, two small particle bupivacaine aerosols (mass median diameters 1.0 and 1.7 micron) were administered on separate occasions to spontaneously breathing anesthetized dogs. Both aerosols resulted in a small but statistically significant increase in VT and one produced an increase in f. The pulmonary chemoreflex to right heart injection of capsaicin, the cough reflex and the Hering-Breuer inflation reflex were unaffected. The ability of a large particle aerosol (mass median diameter 4.8 micron) to block these reflexes was also assessed. This aerosol produced a progressive slowing and deepening of breathing which was maximal after 20 min of aerosol inhalation. Ten min of this aerosol attenuated the pulmonary chemoreflex and abolished the cough and inflation reflexes; 20 min abolished all reflexes. These had recovered by about 1 h after aerosol. Intravenous bupivacaine had no effect on breathing or any reflex. We conclude that a local anesthetic aerosol can block reflexes arising from the alveoli, but not selectively.
为了确定局部麻醉气雾剂是否能选择性地阻断源于肺泡的反射性思维，在不同时间给自主呼吸的麻醉犬分别给予两种小颗粒布比卡因气雾剂（质量中值直径分别为1.0和1.7微米）。两种气雾剂均导致潮气量（VT）有小幅但具有统计学意义的增加，其中一种使呼吸频率（f）增加。右心注射辣椒素引起的肺化学反射、咳嗽反射和黑林-布雷尔充气反射均未受影响。还评估了大颗粒气雾剂（质量中值直径4.8微米）阻断这些反射的能力。这种气雾剂使呼吸逐渐减慢并加深，吸入气雾剂20分钟后达到最大程度。吸入这种气雾剂10分钟可减弱肺化学反射，并消除咳嗽和充气反射；20分钟可消除所有反射。气雾剂作用约1小时后这些反射恢复。静脉注射布比卡因对呼吸或任何反射均无影响。我们得出结论，局部麻醉气雾剂可阻断源于肺泡的反射，但无选择性。
