Centre for Inflammatory Diseases, Monash University, Clayton, Victoria 3168, Australia; Rheumatology Department, Monash Health, Clayton, Victoria 3168, Australia.
Department of Rheumatology, Royal Prince Alfred Hospital, Sydney NSW 2001, Australia.
Semin Arthritis Rheum. 2024 Apr;65:152354. doi: 10.1016/j.semarthrit.2023.152354. Epub 2024 Jan 14.
Autoimmune rheumatic disease (AIRD) is a collective term, which comprises a group of multisystem inflammatory autoimmune diseases, including connective tissue disease, chronic inflammatory arthritis, sarcoidosis and systemic vasculitis. Some AIRD are prevalent in the general population, and all can cause significant morbidity and reduced quality of life, with some increasing the risk of premature mortality, such as systemic lupus erythematosus (SLE), a connective tissue disease that is more prevalent and severe in Australian Aboriginal and Torres Strait Islander Peoples with high mortality rates. To ensure that management of AIRD can be optimised for all Australians, it is important that we understand the prevalence and potential phenotypic variations of AIRD across the Australian population. However, to date there have been few described cases of AIRD other than SLE in Aboriginal and Torres Strait Islander Peoples. In this review, we summarise what is known about AIRD other than SLE in Aboriginal and Torres Strait Islander Peoples, particularly with regards to prevalence, phenotype and disease outcomes, and highlight the current gaps in knowledge.
自身免疫性风湿病 (AIRD) 是一个统称，它包含了一组多系统炎症性自身免疫性疾病，包括结缔组织病、慢性炎性关节炎、结节病和系统性血管炎。一些 AIRD 在普通人群中较为普遍，所有这些疾病都会导致严重的发病率和生活质量下降，有些疾病还会增加过早死亡的风险，如系统性红斑狼疮 (SLE)，这是一种结缔组织病，在澳大利亚原住民和托雷斯海峡岛民中更为普遍和严重，死亡率较高。为了确保所有澳大利亚人都能得到 AIRD 的最佳治疗，了解澳大利亚人群中 AIRD 的患病率和潜在表型变化非常重要。然而，迄今为止，除了 SLE 之外，在原住民和托雷斯海峡岛民中描述的 AIRD 病例很少。在这篇综述中，我们总结了除 SLE 之外在原住民和托雷斯海峡岛民中已知的 AIRD，特别是关于患病率、表型和疾病结局，并强调了目前知识的空白。
