Davis Timothy M E, Bundell Christine S, Chubb Stephen A Paul, McAullay Daniel, Davis Wendy A
Medical School, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.
Department of Endocrinology and Diabetes, Fiona Stanley and Fremantle Hospitals Group, Perth, Western Australia, Australia.
Intern Med J. 2025 Apr;55(4):659-663. doi: 10.1111/imj.70029. Epub 2025 Mar 18.
The prevalence of autoimmune diabetes was assessed in 113 indigenous and 1555 non-indigenous participants in the Fremantle Diabetes Study Phase II. Both type 1 diabetes (3.5% vs. 8.2%) and latent autoimmune diabetes of adults diagnosed based on glutamic acid decarboxylase antibody (GADA) positivity (1.0% vs. 5.7%) were lower in Aboriginal participants (P = 0.101 and 0.039 respectively). Six Aboriginals with GADA-negative type 2 diabetes were positive for tyrosine phosphatase-related islet antigen 2 antibodies but did not exhibit relative insulin deficiency.
在弗里曼特尔糖尿病研究二期的113名原住民参与者和1555名非原住民参与者中评估了自身免疫性糖尿病的患病率。基于谷氨酸脱羧酶抗体（GADA）阳性诊断的1型糖尿病（3.5%对8.2%）和成人潜伏性自身免疫性糖尿病（1.0%对5.7%）在原住民参与者中均较低（P值分别为0.101和0.039）。6名GADA阴性的2型糖尿病原住民酪氨酸磷酸酶相关胰岛抗原2抗体呈阳性，但未表现出相对胰岛素缺乏。
