Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Center of Excellence for Neural Plasticity and Brain Disorders: BRAINCITY, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Sci Data. 2024 Jan 18;11(1):89. doi: 10.1038/s41597-024-02943-8.
We present a dataset of 1809 single neurons recorded from the human medial temporal lobe (amygdala and hippocampus) and medial frontal lobe (anterior cingulate cortex, pre-supplementary motor area, ventral medial prefrontal cortex) across 41 sessions from 21 patients that underwent seizure monitoring with depth electrodes. Subjects performed a screening task (907 neurons) to identify images for which highly selective cells were present. Subjects then performed a working memory task (902 neurons), in which they were sequentially presented with 1-3 images for which highly selective cells were present and, following a maintenance period, were asked if the probe was identical to one of the maintained images. This Neurodata Without Borders formatted dataset includes spike times, extracellular spike waveforms, stimuli presented, behavior, electrode locations, and subject demographics. As validation, we replicate previous findings on the selectivity of concept cells and their persistent activity during working memory maintenance. This large dataset of rare human single-neuron recordings and behavior enables the investigation of the neural mechanisms of working memory in humans.
我们提供了一个数据集，其中包含 1809 个从 21 名接受深度电极癫痫监测的患者的人类内侧颞叶（杏仁核和海马体）和内侧额叶（前扣带皮层、补充运动前区、腹内侧前额叶皮层）中记录的单个神经元。受试者执行了一项筛选任务（907 个神经元），以识别存在高选择性细胞的图像。然后，受试者执行了一项工作记忆任务（902 个神经元），其中他们依次呈现存在高选择性细胞的 1-3 个图像，在保持期后，他们被问到探针是否与保持的图像之一相同。这个符合 Neurodata Without Borders 格式的数据集中包括尖峰时间、细胞外尖峰波形、呈现的刺激、行为、电极位置和受试者人口统计学信息。作为验证，我们复制了先前关于概念细胞的选择性及其在工作记忆保持期间持续活动的发现。这个包含稀有人类单细胞记录和行为的大型数据集使我们能够研究人类工作记忆的神经机制。
