Bone Diseases CENTER, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Sci Rep. 2024 Jan 18;14(1):1638. doi: 10.1038/s41598-024-51774-5.
The role of dietary patterns in the development of osteoporosis is unclear. The heel quantitative ultrasound (QUS) is a potential alternative to Dual X-Ray Absorptiometry. Nutrients, foods, dietary patterns and compliance to dietary guidelines were compared between the lowest and the highest tertiles of QUS parameters [Broadband Ultrasound Attenuation (BUA), Speed of Sound (SOS), Stiffness Index (SI)], using data from the OsteoLaus cohort. Participants in the highest tertiles of QUS parameters (385 for BUA, 397 for SOS, 386 for SI) were younger, of higher body weight, and had less major osteoporotic fractures. Women in the highest tertiles of SI and BUA consumed more fat (35.1 ± 0.4 vs 33.9 ± 0.4 and 34.9 ± 0.4 vs 33.8 ± 0.4 gr/day for SI and BUA, respectively, p < 0.05), and complied less frequently with dairy intake guidelines [odds ratio (95% confidence interval): 0.70 (0.53-0.92) and 0.72 (0.55-0.95) for SI and BUA, respectively, p < 0.05] than women in the lowest tertile. No differences were found regarding dietary patterns, healthy dietary scores, or compliance to dietary guidelines. Postmenopausal women in the highest QUS tertiles were younger, of higher weight and BMI, consumed more monounsaturated fatty acids and less dairy and calcium than women in the lowest tertiles. No differences were found between QUS tertiles regarding dietary patterns.
膳食模式在骨质疏松症发展中的作用尚不清楚。足跟定量超声（QUS）是双能 X 射线吸收法的潜在替代方法。使用 OsteoLaus 队列的数据，比较了 QUS 参数（宽带超声衰减（BUA）、声速（SOS）、硬度指数（SI））最低和最高三分位数之间的营养素、食物、膳食模式和对膳食指南的依从性。QUS 参数最高三分位组（BUA 为 385，SOS 为 397，SI 为 386）的参与者更年轻，体重更高，且发生主要骨质疏松性骨折的情况更少。SI 和 BUA 最高三分位组的女性摄入更多脂肪（SI 和 BUA 分别为 35.1±0.4 vs 33.9±0.4 和 34.9±0.4 vs 33.8±0.4 克/天，p<0.05），且更不遵守乳制品摄入量指南[比值比（95%置信区间）：SI 和 BUA 分别为 0.70（0.53-0.92）和 0.72（0.55-0.95），p<0.05]。在膳食模式、健康饮食评分或对膳食指南的依从性方面，没有差异。QUS 最高三分位组的绝经后女性比最低三分位组的女性更年轻、体重和 BMI 更高、摄入更多单不饱和脂肪酸、更少的乳制品和钙。在 QUS 三分位组之间，没有发现膳食模式的差异。
