Departments of Pediatrics.
Division of Pediatric Infectious Diseases, Department of Pediatrics.
Pediatrics. 2024 Jan 1;153(2). doi: 10.1542/peds.2022-061047.
Although the 2022 mpox outbreak mostly affected adults, its effect on children and adolescents was also substantial. In this report, we describe the clinical course and treatment of the first 3 known cases of mpox in children in New York City. These cases are instructive because they illustrate various routes of transmission, clinical presentations, and diagnostic challenges that differ from previous reports of mpox in endemic countries and previous mpox outbreaks. Of note is that each of the 3 patients received treatment with tecovirimat under an US Food and Drug Administration expanded access investigational new drug application and improved without exhibiting adverse reactions.
尽管 2022 年猴痘疫情主要影响成年人，但它对儿童和青少年的影响也相当大。在本报告中，我们描述了纽约市已知的首例 3 例儿童猴痘病例的临床经过和治疗。这些病例具有启发性，因为它们说明了与以往流行国家和以往猴痘疫情报告不同的各种传播途径、临床表现和诊断挑战。值得注意的是，这 3 名患者都根据美国食品和药物管理局的扩大准入研究性新药申请接受了特考韦瑞玛治疗，并且没有表现出不良反应而康复。
